METHOD OF PRODUCING DOUBLE CATION-SUBSTITUTED TRICALCIUM PHOSPHATES Russian patent published in 2023 - IPC C01B25/32 C01B25/45 

FIELD: medical materials science.

SUBSTANCE: invention relates to a method of producing double cation-substituted tricalcium phosphates, which can be used in the production of a starting biocompatible material suitable for the manufacture of dense and porous ceramics. The proposed method includes mechanochemical activation of calcium oxide and diammonium phosphate at pH 7.0 using a planetary mill followed by heat treatment, while after mixing calcium oxide and diammonium phosphate, a calculated amount of solutions of nitrate salts of the following elements is added to the reactor: strontium and copper, at the following ratio of reagents, wt. %: 26.8 of calcium oxide, 50.6 of disubstituted ammonium phosphate, 10.2 of strontium salt, up to 100% of copper salt, after which activation is carried out at a planetary mill speed of 1,000 min^-1 for 20 minutes. The powder formed after heat treatment at a temperature of 1,100°C is characterized by a homogeneous phase composition corresponding to the whitlockite structure and antimicrobial activity.

EFFECT: technical result of the invention is to reduce the speed of the planetary mill to 1,000 min¹, as well as to impart simultaneously improved proliferative properties and antibacterial activity to tricalcium phosphate and porous ceramic materials made from it.

1 cl, 7 ex