FIELD: medicine; neurology; therapy.
SUBSTANCE: group of inventions is intended for the treatment of amyotrophic lateral sclerosis (ALS) in a human subject in need of it. A method of treating ALS involves intravenous (IV) bolus injection to a subject of the following: 2–5 mg/kg of a peptide containing the amino acid sequence set forth in the following SEQ ID NO: 1, wherein the said peptide is in a composition comprising Dulbecco's Phosphate Buffered Saline (DPBS) at a concentration of 50 mg/mL, thereby treating ALS in the subject. Also the following is provided: a composition for the treatment of ALS containing Dulbecco's phosphate-buffered saline (DPBS) and a peptide containing the amino acid sequence set forth in the following SEQ ID NO: 1, while the peptide in the composition is at a concentration of 50 mg/ml.
EFFECT: use of the group of inventions provides effective treatment of ALS in a human subject in need of it.
6 cl, 4 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| THERAPEUTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS | 2013 |
|
RU2655811C2 |
| TREATING AUTOIMMUNE DISEASES WITH CD154 ANTIBODIES | 2015 |
|
RU2695443C2 |
| IMPROVED ANTIBODIES BINDING Aβ-PROTOFIBRILS | 2015 |
|
RU2700104C2 |
| APPLICATION OF GROWTH HORMONE FRAGMENTS | 2012 |
|
RU2639474C2 |
| METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASES | 2018 |
|
RU2789485C2 |
| METHODS AND COMPOSITIONS FOR IMPROVED DELIVERY OF MACROMOLECULES | 2009 |
|
RU2522245C2 |
| LIPOSOMES CONTAINING OLIGOPEPTIDE FRAGMENTS OF MYELIN BASIC PROTEIN, PHARMACEUTICAL COMPOSITION AND METHOD FOR MULTIPLE SCLEROSIS TREATMENT | 2013 |
|
RU2639497C2 |
| EARLY DETECTION OF ACTIVATION OF GLIAL CELLS IN NEURODEGENERATIVE OR NEUROINFLAMMATORY DISEASES | 2018 |
|
RU2766341C2 |
| THERAPEUTIC VACCINE | 2006 |
|
RU2440824C2 |
| POLYPEPTIDES SELECTIVE TO GLUCAGON RECEPTORS AND THEIR APPLICATION METHODS | 2017 |
|
RU2760007C2 |
