COMPOSITIONS AND METHODS OF THEIR USE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) Russian patent published in 2023 - IPC A61K9/08 A61K38/08 A61P25/28 A61P25/00 

FIELD: medicine; neurology; therapy.

SUBSTANCE: group of inventions is intended for the treatment of amyotrophic lateral sclerosis (ALS) in a human subject in need of it. A method of treating ALS involves intravenous (IV) bolus injection to a subject of the following: 2–5 mg/kg of a peptide containing the amino acid sequence set forth in the following SEQ ID NO: 1, wherein the said peptide is in a composition comprising Dulbecco's Phosphate Buffered Saline (DPBS) at a concentration of 50 mg/mL, thereby treating ALS in the subject. Also the following is provided: a composition for the treatment of ALS containing Dulbecco's phosphate-buffered saline (DPBS) and a peptide containing the amino acid sequence set forth in the following SEQ ID NO: 1, while the peptide in the composition is at a concentration of 50 mg/ml.

EFFECT: use of the group of inventions provides effective treatment of ALS in a human subject in need of it.

6 cl, 4 tbl, 2 ex