CO-CRYSTAL FORMS OF THEOBROMINE Russian patent published in 2023 - IPC C07D473/10 C07C59/84 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a method of producing co-crystalline forms of theobromine with meglumine and theobromine with tromethamine, where the molar ratio in both cases is 1:1, having peaks at 2θ (°) 7.1537, 8.7228, 9.8027, 12.2524, 15.7677, 17.6967, 19.7111, 21.7759, 23.8743, 26.7889, 28.2331, 36.0912, 37.2491, 41.31 83, 45.6465, 51.4422, 56.4172, 61.5586, 63.7719, 66.0422 and peaks at 2θ (°) 14.0683, 18.1478, 20.0967, 22.4362, 25.1774, 28.5611, 31.8306, 33.7598, 33.9691, 36.5068, 38.2442, 38.3167, 38.4844, 41.9036, 43.2730, 45.6545 according to X-ray diffraction measurements of a polycrystal, respectively, by the method of mechanochemical activation, carried out by supplying a mixture of theobromine with meglumine or theobromine with tromethamine in a planetary porcelain ball mill. Then they are subjected to mechanical action in the presence of methanol, after which the target products are purified by recrystallization from methanol by adsorption of impurities with activated carbon, hot filtration and cooling of the resulting solution.

EFFECT: obtaining co-crystalline forms of theobromine with meglumine or tromethamine, characterized by a high degree of solubility.

1 cl, 10 dwg, 1 tbl, 1 ex