MUCOADHESIVE PHARMACEUTICAL COMPOSITIONS BASED ON CORTICOSTEROIDS Russian patent published in 2023 - IPC A61K31/58 A61K47/10 A61K47/36 A61K9/08 A61K9/10 

FIELD: pharmaceutical industry.

SUBSTANCE: group of inventions relates to a mucoadhesive composition and a method of treating one or more inflammatory conditions of the esophagus, eosinophilic esophagitis or inflammatory bowel disease. A mucoadhesive pharmaceutical composition based on a corticosteroid containing the following ingredients: (a) budesonide in an amount of 0.02–0.06 wt./wt.% of the composition, (b) glycerin in an amount of 40–70 wt./wt.% of the composition, (c) xanthan gum in an amount of 0.25–1.5 wt./wt.% of the composition, and (d) propylene glycol in an amount of not more than 20 wt./wt.% of the composition, the composition having a pH of 4.5 to 7. A method of treating one or more inflammatory conditions of the esophagus, eosinophilic esophagitis or inflammatory bowel disease, comprising administering the above-described composition to a subject in need thereof.

EFFECT: above composition characterized by good mucoadhesive properties and stability, has local activity and prevents unwanted systemic effects by minimizing the penetration of the active ingredient through the mucous membrane.

15 cl, 8 dwg, 5 ex, 7 tbl