FIELD: chemistry.
SUBSTANCE: composition for use as a contrast agent. The proposed composition contains: 1) a complex of Formula (II) having a diastereomeric excess of at least 80% of a mixture of Formulas II-RRR and II-SSS isomers, and 2) a free macrocyclic ligand, wherein the composition has a free gadolinium concentration of less than 1 ppm (w/v). The composition contains from 0.002 to 0.4 mol/mol % free macrocyclic ligand relative to the complex of Formula (II). The invention also relates to a method for purifying this complex of Formula (II).
(II),
(II-SSS)
(II-RRR)
EFFECT: composition according to the present invention is stable over time.
21 cl, 4 tbl, 2 ex
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