DIMERIC CONTRAST AGENTS Russian patent published in 2020 - IPC C07D403/12 C07D257/02 C07F5/00 C07F9/38 A61K49/12 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I), in which R is -CH(R₁)-COOH, R 1 is H; n is 1; R₂ is selected from a group consisting of: C₁-C₅ alkyl substituted with one or more C₃-C₈ hydroxyalkoxy groups; a group of formula -(CH₂)_sCH(R₃)-G; and C₅-C₁₂ hydroxyalkyl containing at least 2 hydroxyl groups; s is 0; R 3 is H; G is a group selected from -PO(OR₄)₂ and -COOH; R₄ independently represent H; L is C₁-C₆ alkylene, optionally interrupted by one or more groups -N(R'₂)-, R'₂ independently represents what is defined for R₂. Invention also relates to a chelated complex, to a pharmaceutical composition for diagnostic imaging of an organ or tissue of a human or animal body using an MRI method, to a compound of formula (I), wherein each of carboxyl groups of R groups bonded with nitrogen atoms of macrocycles is in protected form in form of tert-butyl ether.

EFFECT: there are prepared new compounds of formula (I), which are used as contrast agents possessing increased relactivity.

19 cl, 1 tbl, 6 ex