NEW GADOLINIUM CHELATE COMPOUNDS WITH HIGH RELAXIVITY FOR USE IN MAGNETIC RESONANCE IMAGING Russian patent published in 2021 - IPC C07D257/02 C07D403/14 A61K49/10 

FIELD: chemistry.

SUBSTANCE: present invention relates to a compound of the general formula (I)

in which R¹ is a hydrogen atom, R² is, independently of each other, a group selected from: C₁-C₆-alkyl, C₃-C₆-cycloalkyl, (C₁-C₃-alkoxy)-(C₂-C₄-alkyl)-, 2-(2-methoxyethoxy)ethyl, 2-(2-ethoxyethoxy)ethyl and phenyl, where the specified C₁-C₆-alkyl group is optionally substituted, equally or differently, with a phenyl group. A method for obtaining a compound of the general formula (I) and its application for magnetic resonance imaging, for the manufacture of diagnostic tools and for the manufacture of contrast agents for magnetic resonance imaging, a method for imaging body tissue in a patient, the use of a compound of the general formula (VII), a compound of the general formula (VIII) and a compound of the general formula (IX), as defined in the claims, are also proposed to obtain a compound of the general formula (I).

EFFECT: proposed compounds belong to a new class of extracellular gadolinium chelate complexes, which have high relaxivity, and which can be used as contrast agents for magnetic resonance imaging.

14 cl, 4 dwg, 5 tbl, 17 ex