FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, particularly to use of non-equvalent mobile protons, relating to different NMR stereoisomers of CEST-agent, in ratiometric imaging method using CEST and to complex lanthanide compounds (III), having at least two distinguishable by NMR stereoisomers in solution used as sensitive CEST-agents not depending on concentration.
EFFECT: distinguished by NMR stereoisomers of CEST-agent are applied as useful biomarkers of certain disease, preciously associated with these changes.
13 cl, 21 dwg, 10 ex
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