HETEROCYCLIC COMPOUND Russian patent published in 2022 - IPC C07D401/14 C07D403/04 C07D403/14 C07D405/14 C07D409/14 C07D413/14 C07D417/14 A61K31/4184 A61K31/454 A61K31/505 A61K31/5377 C12N5/77 

FIELD: biotechnology.

SUBSTANCE: invention relates to a compound of the formula (I) or its pharmacologically acceptable salt, where ring A is a benzol ring; ring B is a benzol ring; ring C is an imidazole ring optionally additionally substituted with C_1-6 alkyl group; L is a bond or a methylene group; R¹ is (1) a hydrogen atom, (2) a halogen atom, (3) di-C_1-6 alkylamino group, (4) pyrrolyl, or (5) piperidyl, piperazinyl optionally substituted with one C_1-6 alkyl group, or morpholinyl; and ring D is (1) a benzol ring optionally additionally substituted with 1-3 substitutes selected from (a) a halogen atom, (b) a hydroxy group, (c) C_1-6 alkyl group optionally substituted with 1 C_1-6 alkoxy group, (d) C_1-6 alkoxy group optionally substituted with 1 substitute selected from (i) a carboxy group, (ii) C_1-6 alkoxycarbonyl group, (iii) a benzyloxycarbonyl group, (iv) a carbamoyl group optionally mono- or di-substituted with substitute(s) selected from (I) C_1-6 alkyl group optionally substituted with 1-3 substitutes selected from (A) cyclopropyl, (B) phenyl, (C) phenylamino optionally substituted with 1-3 halogen atoms, (D) pyridyl, (E) tetrahydropyranyl, and (F) a carbamoyl group optionally mono- or di-substituted with substitute(s) selected from C_1-6 alkyl group and 2-phenylethyl, (II) C_2-6 alkenyl group optionally substituted with one phenyl, (III) C_3-10 cycloalkyl group optionally substituted with 1 C_1-6 alkyl group, (IV) a phenyl group optionally substituted with 1 substitute selected from (A) a halogen atom and (B) C_1-6 alkyl group, (V) benzyl, (VI) pyridyl, and (VII) tetrahydropyranyl or 1,1-dioxydihydrobenzothienyl, and (v) pyrrolidinylcarbonyl, morpholinylcarbonyl, 1,1-dioxydothiazolidinylcarbonyl, or piperidylcarbonyl optionally substituted with 1 or 2 substitutes selected from (I) a hydroxy group and (II) C_1-6 alkyl group, and (e) benzyloxy, (2) a cyclohexane ring, (3) a pyridine ring, (4) an isoxazole ring, (5) a thiophene ring, (6) a piperidine ring optionally additionally substituted with 1-3 C_1-6 alkoxycarbonyl groups, or (7) a tetrahydropyran ring.

EFFECT: new compounds are obtained, which can be used as a cardiomyocyte maturation promotor.

10 cl, 8 dwg, 5 tbl, 73 ex