FIELD: biotechnology.
SUBSTANCE: invention concerns a new strain of foot-and-mouth disease virus Aphtae epizooticae genotype O/EA-2, Picornaviridae family, genus Aphthovirus, deposited in the All-Russian State Collection of Exotic Types of Foot-and-Mouth Disease Virus and Other Animal Pathogens (GKSM) FGBI "ARRIAH" under registration number No.412 - dep / 22-46 — GKShM FGBI "ARRIAH" strain "O/Kenya/2017" genotype O/EA-2 of foot-and-mouth disease virus. The presented strain is reproduced in transplanted cell cultures of Siberian mountain ibex kidney (PSGK-30), pig kidney (IB-RS-2), new-born Syrian hamster kidney (VNK-21). In a continuous suspension culture of Syrian hamster kidney cells VNK-21/SUSP/ARRIAN for 10.25± 0.49 hours of incubation, the concentration of the 146S component of the strain "O/Kenya/2017" of the genotype O of the foot and mouth disease virus has an average value of 1.32 ± 0.08 mcg/cm3 (70.94± 0.95%), retaining the original characteristics when passaged in cell culture VNK-21/SUSP/ARRIAH.
EFFECT: presented strain can be used for the manufacture of biopreparations for the diagnosis and specific prevention of FMD genotype O/EA-2 and to control the antigenic activity of FMD vaccines.
1 cl, 1 dwg, 4 tbl, 5 ex
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