FIELD: pharmaceuticals.
SUBSTANCE: extended-release injectable pharmaceutical composition is proposed, the said composition comprising 3-acylnaltrexone or a pharmaceutically acceptable salt thereof, a biocompatible organic solvent and, optionally, a biocompatible polymeric material. Also the following is provided: a method of treating opioid use disorder or alcoholism, comprising administering an injectable sustained release pharmaceutical composition to a subject in need thereof.
EFFECT: pharmaceutical composition provides an extended-release profile after one single injection, and plasma levels of naltrexone in minipigs can provide an extended-release over 2 months.
6 cl, 6 ex, 9 tbl, 8 dwg
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