FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine. Described is thinly liquid composition for subcutaneous injections containing buprenorphine in form of free base or pharmaceutically acceptable salt thereof, biodegradable thermoplastic poly(DL-lactide-co-glycolide) and N-methyl-2-pyrrolidone as biocompatible polar aprotonic liquid. Buprenorphine delivery system with prolonged release includes thinly liquid composition and solid implant for prolonged release buprenorphine. Implant is formed from flowing composition.
EFFECT: buprenorphine delivery system with prolonged release provides in situ 1-month and 3-month release profiles, characterised by extremely high bioavailability, minimum risk of stable tissue injuries and, as a rule, no risk of necrosis of muscles.
19 cl, 5 dwg, 6 tbl, 5 ex
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