FIELD: rapamycin derivatives.
SUBSTANCE: invention is related to a compound of formula (I) or a pharmaceutically acceptable salt thereof, where R1 is selected from the group consisting of hydroxy, 
, 
, 
and 
; and R2 is selected from the group consisting of 
, 
, 
, where m equals 0; n is 1 or 2; and R3 represents hydrogen, C1-6 alkyl or hydroxy-C1-6 alkyl. The invention is also related to a pharmaceutical composition for inhibiting mTOR activity based on the specified compound.
EFFECT: new compounds and a pharmaceutical composition based on them have been obtained, which can be used in medicine to prevent or treat a disorder or disease mediated by the mTOR pathway.
33 cl, 16 dwg, 20 ex
| Title | Year | Author | Number |
|---|---|---|---|
| N-7 SUBSTITUTED PURINES AND PYRAZOLOPYRIMIDINES, COMPOSITIONS THEREOF AND METHODS FOR USE | 2010 |
|
RU2515541C2 |
| N-9-SUBSTITUTED PURINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | 2010 |
|
RU2607635C2 |
| HETEROCYCLIC IMMUNOMODULATORS AS INHIBITOR OF IMMUNE RESPONSE CHECKPOINTS PDL1 | 2020 |
|
RU2824127C2 |
| MORPHOLINO-SUBSTITUTED DERIVATIVES OF UREA OR CARBAMATE AS MTOR INHIBITORS | 2012 |
|
RU2616619C2 |
| NEW QUINOLINE COMPOUNDS | 2018 |
|
RU2810113C2 |
| NEW SPIROBICYCLIC ANALOGUES | 2018 |
|
RU2789377C2 |
| COMPOUNDS BASED ON PYRAZOLOPYRIDINONE | 2018 |
|
RU2806751C2 |
| COMPOUNDS BASED ON PYRAZOLOPYRIDINONE | 2018 |
|
RU2806625C2 |
| 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND VARIANTS OF THEIR USE | 2018 |
|
RU2795850C2 |
| NITROGEN-CONTAINING HETEROCYCLIC AROMATIC COMPOUND, METHOD FOR PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION BASED THEREON AND USE THEREOF | 2017 |
|
RU2729999C1 |
