FIELD: rapamycin derivatives.
SUBSTANCE: invention is related to a compound of formula (I) or a pharmaceutically acceptable salt thereof, where R1 is selected from the group consisting of hydroxy, 
, 
, 
and 
; and R2 is selected from the group consisting of 
, 
, 
, where m equals 0; n is 1 or 2; and R3 represents hydrogen, C1-6 alkyl or hydroxy-C1-6 alkyl. The invention is also related to a pharmaceutical composition for inhibiting mTOR activity based on the specified compound.
EFFECT: new compounds and a pharmaceutical composition based on them have been obtained, which can be used in medicine to prevent or treat a disorder or disease mediated by the mTOR pathway.
33 cl, 16 dwg, 20 ex
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