CHIRAL COMPOSITE VOLTAMMETRIC SENSOR FOR DETERMINING NAPROXEN ENANTIOMERS Russian patent published in 2023 - IPC G01N27/26 G01N33/68 

FIELD: electroanalytical chemistry.

SUBSTANCE: chiral voltammetric sensor for selective recognition and determination of enantiomers of naproxen, made of glassy carbon with an applied composite modifier consisting of a mixture of the polyelectrolyte complex chitosan-chitosan succinamide and chelate complexes of the general structure [Me(Ln)_x(Ln')_y] or [Me(Ln)_x(Ln')_y(H2O)_z], where Me is a Cu(II) or Zn(II) ion; Ln and Ln' are enantiomers of α-amino acids, non-electroactive in the accessible potential range, taken in the ratio of 0.002-0.02 g of chelate complex per 2 ml of 0.005% solution of the chitosan-chitosan succinamide polyelectrolyte complex.

EFFECT: ability to determine the content of individual enantiomers of the optically active substance of the drug Naproxen in aqueous solutions, urine and blood plasma using an electroanalytical method.

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