FIELD: electrochemistry.
SUBSTANCE: invention relates to electrochemistry and can be used to improve enantioselectivity of recognition and determination of the optically active substance of the drug "Naproxen" in model solutions, as well as biological fluids. Enantioselective composite voltammetric sensor is made from a glass-carbon electrode with a composite chiral modifier deposited on the working surface, consisting of a mixture polyelectrolyte complex chitosan-succinamide of chitosan, betulinic acid and aluminophosphate zeolite AlPO4-11, taken in ratio of 1 ml of mixture of polyelectrolyte complex with betulinic acid to 4 mg of aluminophosphate zeolite.
EFFECT: invention enables to determine in a wide linear range the signal of naproxen enantiomers differentiated by two enantioselectivity parameters (ip1/ip2, ΔEp) due to manifestation of synergetic effect of betulinic acid with aluminophosphate zeolite AlPO4-11, deposited on the surface of the sensor.
1 cl, 4 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| CHIRAL COMPOSITE VOLTAMMETRIC SENSOR FOR DETERMINING NAPROXEN ENANTIOMERS | 2023 |
|
RU2807488C1 |
| VOLTAMMETRIC SENSOR FOR RECOGNITION AND DETERMINATION OF TYROSINE ENANTIOMERS | 2024 |
|
RU2820023C1 |
| METHOD OF DETERMINING TRYPTOPHAN IN MODEL AQUEOUS SOLUTIONS BY CYCLIC VOLTAMMETRY ON GRAPHITE ELECTRODE MODIFIED WITH COLLOIDAL SILVER PARTICLES | 2024 |
|
RU2823171C1 |
| METHOD OF OBTAINING CHIRAL PLANAR PLATE FOR THIN LAYER CHROMATOGRAPHY OF OPTICAL ISOMERS | 2012 |
|
RU2545315C2 |
| METHOD OF SEPARATING CHIRAL SULFOXIDES USING ENANTIO-SELECTIVE CHROMATOGRAPHY | 2006 |
|
RU2310505C1 |
| METHOD OF AMINE SPLIT EFFECTIVE FOR TREATMENT OF DISORDERS ASSOCIATED WITH INSULIN RESISTANCE SYNDROME | 2004 |
|
RU2344131C2 |
| METHOD FOR SEPARATION OF RACEMIC 3-(2-METHOXYPHENOXY)-1,2- PROPANEDIOL AND 3-(2-METHYLPHENOXY)-1,2-PROPANEDIOL FOR ENANTIOMERS | 2002 |
|
RU2213724C1 |
| SOLUTION FOR PREPARING CHITOSAN MATERIAL, METHOD FOR PREPARING HAEMOSTATIC MATERIAL OF THIS SOLUTION (VERSIONS) AND MEDICAL DEVICE WITH USING CHITOSAN FIBRES | 2011 |
|
RU2487701C2 |
| METHOD FOR DETERMINATION OF ENANTIOMERIC EXCESS OF CHIRAL COMPOUNDS (VERSIONS) | 2015 |
|
RU2610352C1 |
| N-(2-ARYLPROPIONYL)SULFONAMIDES AND PHARMACEUTICAL PREPARATION COMPRISING THEREOF | 1999 |
|
RU2255084C2 |
