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2 814 614

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IPC

G01N27/36(2006-01-01)

G01N27/327(2006-01-01)

(21) (22)

Application

2023127215, 2023-10-24

(24)

Start date

2023-10-24

(22)

Actual filing date

2023-10-24

(45)

Published

2024-03-01

(72)

Inventor

Zilberg Rufina AlekseevnaBulysheva Elena OlegovnaTeres Iuliia BorisovnaVakulin Ivan Valentinovich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Obrazovatelno Uchrezhdenie Vysshego Obrazovaniia Universitet Nauki I Tekhnologii"

ENANTIOSELECTIVE COMPOSITE VOLTAMMETRIC SENSOR BASED ON COMBINATION OF AlPO-11 ALUMINOPHOSPHATE ZEOLITE AND BETULINIC ACID Russian patent published in 2024 - IPC G01N27/36 G01N27/327

Abstract RU 2814614 C1

FIELD: electrochemistry.

SUBSTANCE: invention relates to electrochemistry and can be used to improve enantioselectivity of recognition and determination of the optically active substance of the drug "Naproxen" in model solutions, as well as biological fluids. Enantioselective composite voltammetric sensor is made from a glass-carbon electrode with a composite chiral modifier deposited on the working surface, consisting of a mixture polyelectrolyte complex chitosan-succinamide of chitosan, betulinic acid and aluminophosphate zeolite AlPO₄-11, taken in ratio of 1 ml of mixture of polyelectrolyte complex with betulinic acid to 4 mg of aluminophosphate zeolite.

EFFECT: invention enables to determine in a wide linear range the signal of naproxen enantiomers differentiated by two enantioselectivity parameters (i_p1/i_p2, ΔE_p) due to manifestation of synergetic effect of betulinic acid with aluminophosphate zeolite AlPO₄-11, deposited on the surface of the sensor.

1 cl, 4 tbl

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RU 2 814 614 C1

Authors

Zilberg Rufina Alekseevna

Bulysheva Elena Olegovna

Teres Iuliia Borisovna

Vakulin Ivan Valentinovich

Dates

2024-03-01—Published

2023-10-24—Filed