TREATMENT OF DISEASES ASSOCIATED WITH FRATAXIN (FXN), BY INHIBITING NATURAL ANTISENSE FXN TRANSCRIPT Russian patent published in 2017 - IPC C12N15/113

Abstract RU 2620980 C2

FIELD: pharmacology.

SUBSTANCE: oligonucleotides are decsribed, modulating the expression of frataxin (FXN), in particular, by targeting the interaction with the natural antisense polynucleotides of frataxin (FXN). The present invention also relates to the use of the said oligonucleotides for treatment of diseases and disorders associated with the frataxin expression (FXN).

EFFECT: invention expands the arsenal of agents for treatment of diseases and disorders associated with the frataxin expression.

3 cl, 5 dwg, 3 tbl, 3 ex

Similar patents RU2620980C2

Title	Year	Author	Number
TREATMENT OF SODIUM CHANNEL, VOLTAGE-GATED, ALPHA SUBUNIT (SCNA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO SCNA	2011	Kollard Dzhozef Khorkova Sherman Olga De Leon Belinda Kojto Karlos Khsyao Dzhejn Kh., Dr.	RU2588654C2
TREATMENT OF ALPHA-L-IDURONIDASE (IDUA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IDUA	2011	Kollard Dzhozef Khorkova Sherman Olga Kojto Karlos Gang Shen	RU2597972C2
TREATMENT OF DISEASES, ASSOCIATED WITH PROTEIN OF PROSTATE APOPTOTIC RESPONSE PAR4, BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT OF PAR4 GENE	2011	Kollard Dzhozef Khorkova Sherman Ol'Ga	RU2575608C2
TREATMENT OF DISEASES RELATED WITH GENE DLG BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT OF DLG GENE	2011	Kollard Dzhozef Khorkova Sherman Olga Kojto Karlos	RU2611190C2
TREATMENT OF INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1 (IFRD1) ASSOCIATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IFRD1	2011	Kollard Dzhozef Khorkova Sherman Olga Kojto Karlos	RU2611195C2
TREATMENT OF DISEASES ASSOCIATED WITH THE SIALIDASE 4 (NEU4) GENE, BY GENE NEU4 NATURAL ANTISENSE TRANSCRIPT INHIBITION	2011	Kollard Dzhozef Khorkova Sherman Olga	RU2624048C2
TREATMENT OF DISEASES ASSOCIATED WITH METHIONINE SULFOXIDE REDUCTASE A (MSRA), BY MSRA NATURAL ANTISENSE TRANSCRIPT INHIBITION	2011	Kollard Dzhozef Khorkova Sherman Olga	RU2620978C2
TREATING DISEASES, ASSOCIATED WITH NANOG, BY INHIBITION OF NATURAL ANTISENSE NANOG TRANSCRIPT	2011	Kollard Dzhozef Khorkova Sherman Olga	RU2608493C2
TREATMENT OF DISEASES ASSOCIATED WITH ATONAL HOMOLOG 1 (ATON1) BY INHIBITING NATURAL ANTISENSE TRANSCRIPT OF GENE ATON1	2011	Kollard Dzhozef Khorkova Sherman Olga	RU2585229C2
TREATMENT OF PANCREATIC DEVELOPMENTAL GENE RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO PANCREATIC DEVELOPMENTAL GENE	2011		RU2612161C2

RU 2 620 980 C2

Authors

Kollard Dzhozef

Khorkova Sherman Olga

Dates

2017-05-30—Published

2012-06-08—Filed