FIELD: medicine; pharmaceutics.
SUBSTANCE: group of inventions relates to a multicomponent carrier of the "core-shell" type for the delivery of nanostructured components, having an ROS-dependent apoptosis mechanism and having a photothermal effect, into a tumor cell or a cell forming its microenvelopment, which includes gold nanoparticles in the nucleus as nanostructured components having an ROS-dependent apoptosis mechanism, and selenium nanoparticles as nanostructured components having a photothermal effect, and in a shell comprising polymer layers made of poly(allylamine) hydrochloride, poly(sodium 4-styrene sulphonate), also relates to a method of producing a multicomponent carrier, consisting in the fact that an aqueous solution of calcium chloride is mixed with selenium nanoparticles and gold nanoparticles, then sodium carbonate is added dropwise to the obtained mixture with continuous stirring at 1,000 rpm for 30 s at room temperature to obtain calcium carbonate nuclei, then calcium carbonate nuclei containing selenium nanoparticles and gold nanoparticles are coated with polymer layers as follows: calcium carbonate cores with nanoparticles are washed with water and a poly(allylamine) hydrochloride solution is added thereto, then the calcium carbonate nuclei with nanoparticles are washed with water 2 times and a solution of poly(4-sodium styrene sulphonate) is added, obtained suspension is treated with ultrasound and stirred at room temperature, and repeated coating with polymer layers 6 times to form "core-shell" particles, then the calcium carbonate nuclei are removed by dissolving in a solution of ethylenediaminetetraacetic acid, also relates to the use of a multicomponent carrier for the delivery of nanostructured components having an ROS-dependent apoptosis mechanism and having a photothermal effect, into a tumor cell or a cell forming its microenvelopment, by means of intratumoral introduction to a subject for therapy of malignant neoplasms.
EFFECT: group of inventions provides obtaining polymer carriers with included photo- and bioactive nanostructured components, their application in medicine, namely in delivery of biologically active compounds for therapy of malignant new growths (MNG).
4 cl, 5 dwg, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING PHARMACEUTICALLY ACCEPTABLE DOSAGE FORMS AND USING THEM IN COMBINED CHEMOTHERAPY AND PHOTODYNAMIC THERAPY OF MALIGNANT NEOPLASMS | 2023 |
|
RU2822629C1 |
| METHOD OF SELECTIVE DESTRUCTION OF MALIGNANT CELLS BY MAGNETIC MICROCONTAINERS WITH PHOTODYNAMIC OR PHOTOTHERMAL DYES | 2009 |
|
RU2405600C9 |
| PARTICLES CONTAINING BILIRUBIN DERIVATIVE AND METAL | 2018 |
|
RU2756753C2 |
| METHOD FOR PLASMON-RESONANCE PHOTOTHERMAL TUMOUR THERAPY IN EXPERIMENT | 2015 |
|
RU2614507C1 |
| CONJUGATE OF NANOPARTICLES OF GOLD-MAGNETITE COMPOSITION WITH FUNCTIONAL MOLECULE (OPTIONS) AND METHOD OF USE (OPTIONS) | 2023 |
|
RU2811020C1 |
| METHOD OF LASER HYPERTHERMIA OF TUMORS WITH THE INTRODUCTION OF PLASMON RESONANCE NANOPARTICLES USING THE TECHNIQUE OF IMMERSION OPTICAL CLEARANCE | 2022 |
|
RU2800156C1 |
| IMAGING SYSTEM AND METHOD OF PRODUCING IMAGING SYSTEMS BASED ON NANOPARTICLES AND USE THEREOF TO INCREASE EFFICIENCY OF RADIOLOGICAL METHODS OF INVESTIGATING MALIGNANT NEOPLASMS | 2023 |
|
RU2818267C1 |
| SOLID-PHASE METHOD OF PRODUCTION OF WATER-SOLUBLE BIOACTIVE NANOCOMPOSITE BASED ON HYALURONIC ACID MODIFIED BY CITRIC ACID AND GOLD NANOPARTICLES | 2013 |
|
RU2534789C1 |
| METHOD OF PROTON THERAPY FOR SOLID EHRLICH CARCINOMA | 2023 |
|
RU2808984C1 |
| METHODS FOR COMBINED THERAPY OF MALIGNANT NEOPLASMS USING IRON OXIDE NANOPARTICLES | 2023 |
|
RU2816227C1 |
