IMMUNOGENIC PRODUCT CONTAINING IL-4 AND/OR IL-13 FOR TREATMENT OF DISORDERS ASSOCIATED WITH ABERRANT EXPRESSION OR ACTIVITY OF IL-4 AND/OR IL-13 Russian patent published in 2023 - IPC A61K38/20 A61K39/00 A61K47/64 A61P11/06 A61P37/00 

FIELD: pharmaceuticals; medicine.

SUBSTANCE: object 1 is an immunogenic product for treating an inflammatory disorder, comprising at least one cytokine conjugated to a carrier protein, wherein at least one cytokine is IL-13 or a mammalian variant of IL-13, wherein this variant exhibits at least 80% identity with the mammalian IL-13 from which it is derived, the carrier protein being CRM₁₉₇. Object 2 is a composition for the treatment of an inflammatory disorder containing at least one immunogenic product. Object 3 is a method of producing an immunogenic product using a heterobifunctional cross-linking agent containing an NHS ester. Objects 4 and 5 are the use of an immunogenic product or composition for treating an inflammatory disorder associated with aberrant expression or activity of IL-13, and for inducing desensitization of a subject allergic to a specific antigen.

EFFECT: effectiveness of the immunogenic product and the production of neutralizing antibodies upon its administration.

16 cl, 16 dwg, 13 tbl, 12 ex