FIELD: chemistry.
SUBSTANCE: invention relates to organic and medical chemistry, a novel biologically active substance of the class of substituted 4,5-dihydro-1H-pyrrole-3-carboxylic acids. Disclosed is ethyl ester (E)-2-amino-5-(2-(naphthalen-2-yl)-2-oxoethylidene)-4-oxo-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4,5-dihydro-1H-pyrrole-3-carboxylic acid of formula 1.
EFFECT: obtaining a derivative of substituted 4,5-dihydro-1H-pyrrole-3-carboxylic acids with pronounced anticancer activity against colorectal cancer and low toxicity.
1 cl, 2 tbl, 3 ex
| Title |
Year |
Author |
Number |
| ETHYL ETHER 2-AMINO-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)-5-(2-(4-ETHYLPHENYL)-2-OXOETHYLIDENE)-4-OXO- 4,5-DIHYDRO-1H-PYRROL-3-CARBOXYLIC ACID WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
- Parkhoma Kseniia Iurevna
|
RU2810070C1 |
| AMIDE OF 2-AMINO-4-OXO-5-(2-OXO-2-(4-CHLOROPHENYL)ETHYLIDENE)-1-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-YL)-4,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLIC ACID, HAVING ANTICANCER ACTIVITY ON MELANOMA |
2024 |
- Rogova Anna
- Timin Aleksandr Sergeevich
- Shipilovskikh Sergei Aleksandrovich
|
RU2836299C1 |
| (E)-5-AMINO-2-OXO-1-(2-(NAPHTHALEN-2-YL)-2-OXOETHYLIDENE)-1,2,6,7,8,9-HEXAHYDROBENZO[4,5]THIENO[3,2-E]PYRROLO[1,2-A]PYRIMIDINE-3-CARBOXAMIDE, HAVING ANTICANCER ACTIVITY IN BREAST CANCER THERAPY |
2023 |
- Karpov Timofei Evgenevich
- Rogova Anna
- Timin Aleksandr Sergeevich
- Shipilovskikh Sergei Aleksandrovich
|
RU2820661C1 |
| SUBSTITUTED ETHYL ESTERS (E)-2-(5-AMINO-4-R1-3-OXO-2-(2-OXO-2-(P-TOLYL)ETHYLIDENE)-2,3-DIHYDRO-1H-PYRROL- 1-YL)-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[b]THIOPHENE-3-CARBOXYLIC ACID, WHICH HAS ANTICANCER ACTIVITY IN THE TREATMENT OF LUNG MELANOMA |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Timin Aleksandr Sergeevich
|
RU2806324C1 |
| AMIDE (E)-2-AMINO-4-OXO-5-(2-OXO-2-PHENYLETHYLIDENE)-1-(3-ETHOXYCARBONYL)-4,5,6-7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)4,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLIC ACID, HAVING ANTIMICROBIAL ACTIVITY |
2020 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Tkachenko Aleksandr Georgievich
- Nesterova Larisa Yurevna
|
RU2738405C1 |
| N'-(IMINO(2-((6-(2-METHOXYPHENYL)-2-(4-NITROBENZOYL)-3-OXO-2,3-DIHYDROPYRIDAZIN-4-YL)AMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-3-YL)METHYL)-4-NITROBENZOHYDRAZIDE, HAVING ANTI-INFLAMMATORY ACTIVITY |
2024 |
- Shipilovskikh Sergej Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrij Vladimirovich
|
RU2831250C1 |
| USE OF CYTOTOXIC AGENTS BASED ON SUBSTITUTED POTASSIUM 1-AMINO-1,6-DIOXO-2-CYANO-1-ETHOXY-6-R1-4-[((3-ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-yl)AMINO]HEXA-2,4-DIEN-3-OLATES IN TREATMENT OF LUNG MELANOMA |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Timin Aleksandr Sergeevich
|
RU2808533C1 |
| 1-AMINO-6-(4-METHOXYPHENYL)-1,6-DIOXO-2-CYANO-4-((3-(ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)AMINO)HEXA-2,4-DIENE-3-OLATE SODIUM, HAVING ANTICANCER ACTIVITY IN THERAPY OF BREAST CANCER |
2024 |
- Gorbunova Irina Aleksandrovna
- Mitusova Kseniia Andreevna
- Timin Aleksandr Sergeevich
- Shipilovskikh Sergei Aleksandrovich
|
RU2838409C1 |
| APPLICATION OF AN ANALGESIC AGENT BASED ON ETHYL ETHERS OF 2-[(5-HYDROXY-5-PHENYL-2-OXO-1-R-2,5-DIHYDRO-1H-PYRROLE-3-YL)AMINO]-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-3-CARBOXYLIC ACID |
2021 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Shipilovskikh Darya Aleksandrovna
|
RU2776072C1 |
| 1-AMINO-1,6-DIOXO-6-(4-METHOXYPHENYL)-2-CYANO-4-((3-(ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-YL)AMINO)HEXA-2,4-DIENE-3-OLATE OF SODIUM, HAVING ANALGESIC ACTIVITY |
2024 |
- Timin Aleksandr Sergeevich
- Shipilovskikh Sergei Aleksandrovich
|
RU2834687C1 |
