FIELD: chemistry.
SUBSTANCE: invention relates to organic and medicinal chemistry, namely to amide of 2-amino-4-oxo-5-(2-oxo-2-(4-chlorophenyl)ethylidene)-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4,5-dihydro-1H-pyrrole-3-carboxylic acid of formula 1.
EFFECT: amide of formula 1, having anticancer activity on melanoma and low toxicity on healthy tissues.
1 cl, 2 tbl, 3 ex
| Title |
Year |
Author |
Number |
| (E)-5-AMINO-2-OXO-1-((E)-2-OXO-4-PHENYLBUT-3-EN-1-YLIDENE)-1,2,6,7,8,9-HEXAHYDROBENZO[4,5]THIENO[3,2-E]PYRROLO[1,2-A]PYRIMIDINE-3-CARBOXAMIDE, HAVING ANTICANCER ACTIVITY IN PULMONARY MELANOMA THERAPY |
2023 |
- Karpov Timofei Evgenevich
- Rogova Anna
- Timin Aleksandr Sergeevich
- Shipilovskikh Sergei Aleksandrovich
|
RU2815045C1 |
| SUBSTITUTED ETHYL ESTERS (E)-2-(5-AMINO-4-R1-3-OXO-2-(2-OXO-2-(P-TOLYL)ETHYLIDENE)-2,3-DIHYDRO-1H-PYRROL- 1-YL)-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[b]THIOPHENE-3-CARBOXYLIC ACID, WHICH HAS ANTICANCER ACTIVITY IN THE TREATMENT OF LUNG MELANOMA |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Timin Aleksandr Sergeevich
|
RU2806324C1 |
| USE OF CYTOTOXIC AGENTS BASED ON SUBSTITUTED POTASSIUM 1-AMINO-1,6-DIOXO-2-CYANO-1-ETHOXY-6-R1-4-[((3-ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-yl)AMINO]HEXA-2,4-DIEN-3-OLATES IN TREATMENT OF LUNG MELANOMA |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Timin Aleksandr Sergeevich
|
RU2808533C1 |
| USE OF CYTOTOXIC AGENTS BASED ON SUBSTITUTED (E)-8-(2-OXO-2-R-ETHYLIDENE)-2-R1-3-R2-6-R3-PYRROLO[1,2-a]THIENO[3,2-e]PYRIMIDINE-4,7(5H,8H)-DIONES IN THE TREATMENT OF LUNG MELANOMA |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Timin Aleksandr Sergeevich
|
RU2808534C1 |
| (E)-5-AMINO-2-OXO-1-(2-(NAPHTHALEN-2-YL)-2-OXOETHYLIDENE)-1,2,6,7,8,9-HEXAHYDROBENZO[4,5]THIENO[3,2-E]PYRROLO[1,2-A]PYRIMIDINE-3-CARBOXAMIDE, HAVING ANTICANCER ACTIVITY IN BREAST CANCER THERAPY |
2023 |
- Karpov Timofei Evgenevich
- Rogova Anna
- Timin Aleksandr Sergeevich
- Shipilovskikh Sergei Aleksandrovich
|
RU2820661C1 |
| ETHYL ESTER OF (E)-2-AMINO-5-(2-(NAPHTHALEN-2-YL)-2-OXOETHYLIDENE)-4-OXO-1-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)-4,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLIC ACID, HAVING ANTICANCER ACTIVITY ON COLORECTAL CANCER |
2024 |
- Timin Aleksandr Sergeevich
- Shipilovskikh Sergei Aleksandrovich
|
RU2836297C1 |
| AMIDE (E)-2-AMINO-4-OXO-5-(2-OXO-2-PHENYLETHYLIDENE)-1-(3-ETHOXYCARBONYL)-4,5,6-7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)4,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLIC ACID, HAVING ANTIMICROBIAL ACTIVITY |
2020 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Tkachenko Aleksandr Georgievich
- Nesterova Larisa Yurevna
|
RU2738405C1 |
| ETHYL ETHER 2-AMINO-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)-5-(2-(4-ETHYLPHENYL)-2-OXOETHYLIDENE)-4-OXO- 4,5-DIHYDRO-1H-PYRROL-3-CARBOXYLIC ACID WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
- Parkhoma Kseniia Iurevna
|
RU2810070C1 |
| N-(3-ETHOXYCARBONYL-4,5,6,7-TETRAHYDROBENZO[b]THIEN-2-YL)AMIDE OF (Z)-4-MORPHOLINO-2-OXO-4-(4-CHLOROPHENYL)BUT-3-ENOIC ACID, POSSESSING ANALGETIC ACTIVITY |
2014 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgen'Evich
- Makhmudov Ramiz Ragibovich
- Panchenko Aleksej Olegovich
|
RU2560522C1 |
| 5-AMINO-3-(MORPHOLINE-4-CARBONYL)-1-(2-OXO-2-(4-FLUOROPHENYL)ETHYLIDENE)-6,7,8,9-TETRAHYDROBENZO[4,5]THIENO[3,2-E]PYRROLO[1,2-A]PYRIMIDIN-2(1H)-ONE, HAVING ANTI-INFLAMMATORY ACTIVITY |
2024 |
- Shipilovskikh Sergej Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Gorbunova Irina Aleksandrovna
- Parkhoma Kseniya Yurevna
|
RU2831363C1 |
