FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a composition for the treatment or prevention of obesity. The use of a pharmaceutical composition containing an amphiregulin-specific double-stranded oligonucleotide, a double-stranded oligo-RNA that contains hydrophilic and hydrophobic compounds connected to an amphiregulin-specific double-stranded oligonucleotide, or nanoparticles containing a double-stranded oligo-RNA is proposed. The amphiregulin-specific double-stranded oligonucleotide contains a sequence selected from SEQ ID NO: 10, 11 and 12, and an antisense strand complementary to the sequence of the sense strand.
EFFECT: invention provides weight loss, a decrease in the nutritional efficiency coefficient, a decrease in subcutaneous fat, a decrease in visceral fat, a decrease in the area of adipocytes and inhibition of liver adipogenesis.
24 cl, 28 dwg, 10 tbl, 10 ex
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Number |
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