FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular, to new double-stranded oligonucleotide structures, and can be used in medicine. Invention discloses a genetic construct wherein a hydrophilic and hydrophobic material is attached to the ends of an androgen receptor-specific oligonucleotide. Such a genetic construct is capable of forming nanoparticles in an aqueous solution, thereby acting as an effective means of intracellular delivery of a therapeutic agent.
EFFECT: invention can be used in medicine to prevent hair loss or enhance hair growth in case of androgenetic alopecia, focal alopecia, and telogen effluvium in a subject.
29 cl, 4 ex, 5 tbl, 9 dwg
| Title |
Year |
Author |
Number |
| COMPOSITION FOR PREVENTION OR TREATMENT OF DISEASE ASSOCIATED WITH OBESITY, CONTAINING AMPHIREGULIN-SPECIFIC DOUBLE-CHAIN OLIGONUCLEOTIDE STRUCTURE |
2021 |
- Park, Jun Hong
- Park, Han-Oh
- Yun, Sung Il
- Kim, Tae Rim
- Hwang, Soo Hyun
- Song, Kang
- Jung, Sang Hyuk
- Kim, Jangseon
- Lee, Mi Sun
- Choi, Soonja
- Son, Seung-Seob
|
RU2810514C1 |
| DOUBLE-CHAINED OLIGONUCLEOTIDE SPECIFIC TO CTGF GENE AND COMPOSITION CONTAINING IT FOR PREVENTION AND TREATMENT OF FIBROUS DISEASES AND DISEASES ASSOCIATED WITH RESPIRATORY SYSTEM |
2020 |
- Park, Han-Oh
- Kim, Tae-Rim
- Ko, Young-Ho
- Yun, Sung Il
- Park, Jun Hong
|
RU2807108C1 |
| COMPOSITION FOR REDUCING HAIR GRAYING, STIMULATING HAIR GROWTH AND/OR PREVENTING OR REDUCING HAIR LOSS, CONTAINING DOUBLE-STRANDED MCRNA AS ACTIVE INGREDIENT |
2022 |
- Park, Han-Oh
- Lee, Sang-Kyu
- Kwon, Oh Seung
- Goh, Eun-Ah
|
RU2823325C1 |
| AMPHIREGULIN GENE-SPECIFIC DOUBLE-STRANDED OLIGONUCLEOTIDES AND COMPOSITIONS CONTAINING THEM FOR THE PREVENTION AND TREATMENT OF FIBROSIS-RELATED DISEASES AND RESPIRATORY DISEASES |
2019 |
- Kim, Tae-Rim
- Yoon, Pyoung Oh
- Ko, Youngho
- Bae, Seon Joo
- Park, Han-Oh
- Son, Seung Seob
- Jun-Hong, Park
- Yun, Sung Il
|
RU2795179C2 |
| DETERMINATION OF NUCLEIC ACIDS BY AMPLIFICATION BASED ON INCORPORATION INTO CHAIN |
2014 |
- Ebojgbodin Kevin
- Brummer Mirko
|
RU2694976C1 |
| LIGAND COMPOUNDS, CONJUGATES AND USE THEREOF |
2021 |
- Zhang, Bill Biliang
- Zhao, Haoting
|
RU2819894C1 |
| GENOMIC ENGINEERING |
2014 |
- Church, George M.
- Yang, Luhan
- Cargol, Marc Guell
- Yang, Joyce Lichi
|
RU2764757C2 |
| GENOME ENGINEERING |
2021 |
- Church, George M.
- Yang, Luhan
- Cargol, Marc Guell
- Yang, Joyce Lichi
|
RU2812848C2 |
| SET OF SYNTHETIC OLIGONUCLEOTIDES FOR SIMULTANEOUS GENOTYPING 63 DNA-MARKERS ASSOCIATED WITH BLOOD GROUP AV0, MAIN HAPLOGROUPS OF Y-CHROMOSOME, COLOR OF IRIS OF EYE, HAIR, SKIN AND GENDER, BY PCR WITH SUBSEQUENT HYBRIDISATION |
2020 |
- Ivanovskii Ivan Dmitrievich
- Fesenko Denis Olegovich
|
RU2740575C1 |
| METHOD OF AMPLIFICATION AND IDENTIFICATION OF NUCLEIC ACIDS |
2019 |
- Goepel, Yvonne
- Moll, Pamela
- Reda, Torsten
- Seitz, Alexander
|
RU2811465C2 |
