METHOD OF PERFORMING ORGAN-CONSERVING SURGERY BY VACUUM-ASSISTED BIOPSY OF BREAST TUMOR BED AFTER NEOADJUVANT CHEMOTHERAPY IN PATIENTS WITH HER2-DEPENDENT OR TRIPLE-NEGATIVE BREAST CANCER SUBTYPE Russian patent published in 2023 - IPC A61B10/02 A61B8/08 A61B6/00 

FIELD: medicine; radiation diagnostics.

SUBSTANCE: invention can be used to perform organ-preserving surgery by vacuum-assisted biopsy (VAB) of the breast tumor bed after neoadjuvant chemotherapy in patients with breast cancer of the HER2-dependent or triple-negative subtype. Before starting neoadjuvant chemotherapy, Y3-contrast markers — a nitilon ring and 5 metal clips — are installed into the primary tumor node through a 7G coaxial needle. U3 control of the position of the installed marks is performed. After neoadjuvant systemic therapy, the markers installed before the start of systemic treatment are visualized, and tissues are collected within a radius of 180° or 360°, the resulting tissue samples are labeled as “inner contour”. An X-ray of the removed samples is then taken. If established contrast marks are detected, tissue samples are taken again using a vacuum-assisted biopsy. The obtained tissue samples are marked as an “external” contour, and if the tumor bed marks are located at a distance of less than or equal to 1.0 cm from the pectoralis major muscle, tissue with a radius of 180° is taken, the number of fabric samples at one time is 6. And if the marks are located at a distance of more than 1 cm from the pectoralis major muscle, tissue samples are taken within a radius of 360°, the number of fabric samples at one time is 12.

EFFECT: method increases diagnostic accuracy, eliminates false negative results, and makes it possible to reduce the volume of removed breast tissue to confirm complete pathomorphological regression of the breast tumor after neoadjuvant systemic therapy.

1 cl, 3 dwg, 6 ex