METHOD OF POSTOPERATIVE PAIN RELIEF WHEN PERFORMING DECOMPRESSION AND STABILIZING OPERATIONS ON SPINE IN CANCER PATIENTS WITH CHRONIC PAIN SYNDROME Russian patent published in 2024 - IPC A61K31/192 A61P29/00 

FIELD: medicine; anesthesiology; resuscitation.

SUBSTANCE: invention can be used for postoperative pain relief when performing decompressive and stabilizing operations on the spine in cancer patients with chronic pain syndrome. The method involves intravenous drip administration of Intrafen-Gen, containing 800 mg of ibuprofen in one bottle. The first injection is performed 30 minutes before the end of the operation — 1 bottle diluted with 250 ml of 0.9% physiological sodium chloride solution is used. The second injection is performed on the first postoperative day, during the first 12 hours after surgery, if the pain intensity on the visual analogue scale (VAS) is above 30 mm at rest and 40 mm with movement — half the dose of the second bottle diluted by 250 ml 0.9 % saline sodium chloride solution or during the first day after surgery, if the pain intensity on the visual analogue scale (VAS) is above 30 mm at rest and 40 mm with movement — a whole bottle diluted with 250 ml of 0.9% physiological sodium chloride solution is used. The third injection is performed in the next 12 hours after the second injection — the remaining half dose of the second bottle diluted with 250 ml of 0.9% physiological sodium chloride solution or a whole bottle in the next 12 hours after the second injection is used. The fourth injection is performed in the morning on the second day after surgery — half the dose of the third bottle diluted with 250 ml of 0.9% physiological sodium chloride solution or a whole bottle in the next 12 hours after the third injection is used. The fifth injection is performed 12 hours after the IV injection — the remaining half dose of 3 bottles diluted with 250 ml of 0.9% physiological sodium chloride solution or a whole bottle in the next 12 hours after the fourth injection is used. The sixth and seventh injections are performed on the third day after surgery, half doses of the fourth bottle — twice a day - in the morning and in the evening, diluted with 250 ml of 0.9% saline sodium chloride solution or the whole bottle 12 hours after the fifth injection is used once.

EFFECT: use of the invention makes it possible to provide effective postoperative pain relief in cancer patients with chronic pain syndrome and reduce the incidence of persistent chronic pain syndrome when performing decompressive and stabilizing interventions on the spine, as well as reduce the opioid load of patients in the postoperative period.

1 cl, 1 ex