MODIFIED MITOCHONDRIA AND THEIR USE Russian patent published in 2024 - IPC A61K47/69 C07K19/00 C12N5/00 A61K35/12 A61K38/16 A61P35/00 

Abstract RU 2811467 C2

FIELD: molecular biology; biotechnology; medicine.

SUBSTANCE: invention relates to mitochondria modified by means of a fusion protein, and a pharmaceutical composition containing them as an active ingredient. The mitochondria of the invention can be efficiently delivered to a target, into a cell where they exhibit various effects, or into the body. Modified mitochondria can be used as an antitumor agent in the treatment of various diseases. In addition, a fusion protein containing the protein of interest and a fusion protein containing the targeting protein can be used to modify mitochondria.

EFFECT: invention provides an effective protein delivery system using mitochondria as a carrier for the treatment of diseases.

30 cl, 83 dwg, 12 tbl, 26 ex

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RU 2 811 467 C2

Authors

Han, Kyuboem

Kim, Chun-Hyung

Kim, Yu Jin

Yu, Shin-Hye

Kim, Nayoung

Kim, Mi Jin

Choi, Yong-Soo

Lee, Seo Eun

Dates

2024-01-12Published

2019-04-25Filed