METHOD OF PREDICTING STAGE OF MULTIPLE SCLEROSIS TAKING INTO ACCOUNT INDICATORS OF IMMUNOLOGICAL STATUS Russian patent published in 2024 - IPC G01N33/533 A61B5/00 

FIELD: medicine; neurology.

SUBSTANCE: invention can be used to predict the stage of multiple sclerosis. The percentage of CD3 T-lymphocytes expressing NK-associated antigens CD16+CD56+ on their surface and the percentage of CD19 B-lymphocytes expressing CD5, CD25, CD38, CD40, CD95 antigens on their surface are determined. The coefficient of the stage of multiple sclerosis is calculated using the numerical values of the obtained percentages of these indicators in the regression equation according to the formula: C_ms=NKT*1.59-CD5*0.04-CD25*0.26-CD38*0.2-CD40*0.12+CD95*0.1+9.43, where NKT is the numerical value of the percentage of T-lymphocytes expressing NK-associated antigens CD16+CD56+ on their surface, CD5 is numerical value of the percentage of B-lymphocytes expressing CD5 antigen on their surface, CD25 is numerical value of the percentage of B-lymphocytes expressing CD25 antigen on their surface, CD38 is numerical value of the percentage of B-lymphocytes expressing the CD38 antigen on their surface, CD40 is numerical value of the percentage of B-lymphocytes expressing the CD40 antigen on their surface, CD95 is numerical value of the percentage of B-lymphocytes expressing the CD95 antigen on their surface, 9.43 is a constant coefficient. If C_ms value is equal to or less than 0, then the stage of remission of multiple sclerosis is predicted; if C_ms value is more than 0, the stage of exacerbation of multiple sclerosis is predicted.

EFFECT: invention provides accurate prediction of the further course of multiple sclerosis.

1 cl, 2 ex