BIOMEDICAL CELL PRODUCT WITH ANTI-HER2 SPECIFIC ANTI-TUMOUR ACTIVITY Russian patent published in 2020 - IPC C12N5/783 A61K35/17 A61P35/00 

Abstract RU 2728361 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, specifically to biomedical cell products, and can be used for expression of anti-HER2 CAR. Produced product possesses anti-HER2 specific anti-tumor activity and is presented by populations of anti-HER2 CAR-NK and anti-HER2 CAR-T cells, as well as lymphokine-activated killers with limited period of chimeric antigen receptor expression (3–5 days). Declared product is obtained from autologous mononuclear lymphocytes activated with a human recombinant cytokine preparation and subjected to genetic modification for the purpose of anti-HER2 CAR expression.

EFFECT: product is characterized by an accelerated period of production (less than 9 days), the effectiveness of which is accompanied by simultaneous activation of congenital and adoptive immune responses, intended for treating patients with solid tumors expressing epidermal growth factor receptor (HER2).

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RU 2 728 361 C1

Authors

Kiselevskij Mikhail Valentinovich

Petkevich Alisa Antonovna

Chikileva Irina Olegovna

Anisimova Natalya Yurevna

Dates

2020-07-29Published

2019-10-16Filed