NEW CHEMICAL COMPOUND THAT STIMULATES PRODUCTION OF HUMAN INTERFERON-BETA BY ACTIVATING STING SIGNALING PATHWAY AND METHOD OF ITS PREPARATION Russian patent published in 2024 - IPC C07D333/64 A61K31/381 A61P35/00 

Abstract RU 2811736 C1

FIELD: medicine; pharmaceuticals and oncology.

SUBSTANCE: invention is related to isopropyl ether 5,6-dimethoxy-γ-oxobenzo[b]thiophene-2-butanoic acid of formula I, which stimulates production of human interferon-beta and has antiproliferative activity mediated by human immune cells, induction of interferon beta gene activity, activation of the STING signalling pathway. A method for preparing compound I by reacting 5,6-dimethoxy-γ-oxobenzo[b]thiophene-2-butanoic acid with anhydrous isopropyl alcohol and thionyl chloride, allowing to obtain the target compound with a yield of 85-94%, is also disclosed.

EFFECT: chemical compound and a method of its preparation are proposed.

3 cl, 3 dwg, 2 ex

I

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RU 2 811 736 C1

Authors

Solopova Olga Nikolaevna

Gusev Dmitrij Vasilevich

Kosorukov Vyacheslav Stanislavovich

Sadovskaya Yana Olegovna

Mishina Aleksandra Vladimirovna

Zajchenko Danila Mikhajlovich

Astafeva Yana Romanovna

Moskovtsev Aleksej Aleksandrovich

Dates

2024-01-16Published

2023-11-10Filed