FIELD: chemistry; pharmaceutics.
SUBSTANCE: invention refers to chemistry and pharmaceutics, namely to a combined agent for lung cancer therapy in the form of nanoparticles. Proposed agent contains gefitinib, aluminium 1,8,15,22-tetraxis(phenylsulfanyl)-29H,31H-phthalocyanine hydroxide as a photosensitizer, poloxamer 188, soya phosphatidylcholine and polyvinylpyrrolidone as a cryoprotector with weight ratios of said components, respectively 1-1.2:0.5-0.6:100-120:10-12:150-180.
EFFECT: invention provides a formulation for parenteral administration and having stability, stimulus-sensitive gefitinib release under the effect of radiation and high cytotoxic activity.
1 cl, 3 dwg, 3 ex
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