METHOD OF SELECTIVE DESTRUCTION OF MACROPHAGES IN CELL SUSPENSION AND WHOLE ORGANISM USING COLLOIDAL SILVER PREPARATIONS - PROTARGOL AND COLLARGOL Russian patent published in 2024 - IPC G09B23/28 A61K33/38 A61P43/00 

FIELD: medicine; immunology; experimental medicine.

SUBSTANCE: invention can be used for the selective destruction of macrophages in a cell suspension or in the body. The method involves adding the drug either directly to the nutrient medium for culturing living cells, or introducing it intravenously into the mouse. A colloidal silver preparation, either protargol or collargol, is used as a selective toxic agent for macrophages. When conducting experiments under conditions of artificial cultivation of macrophages isolated from the mouse body, the concentration range is from 10 to 20 μg/ml, exposure is 4 hours with each agent separately. In experiments where the drug is administered directly into the mouse’s body intravenously, a dose of 1 mg/kg of animal weight and an exposure time of 24 hours with each agent separately are used.

EFFECT: use of the invention makes it possible to achieve selective destruction of mouse macrophages while reducing toxicity, minimizing the doses used, good solubility and ease of use.

1 cl, 7 tbl