PHYTOECDYSONES AND THEIR DERIVATIVES FOR USE IN TREATMENT OF PULMONARY DYSFUNCTIONS Russian patent published in 2024 - IPC A61K31/56 A61K31/57 A61K31/575 A61K31/58 A61P11/00 

FIELD: medicine; neurology.

SUBSTANCE: invention discloses the use of a composition containing at least 20-hydroxyecdysone and/or at least one semi-synthetic derivative of 20-hydroxyecdysone in mammals for the treatment of respiratory dysfunction resulting from acquired or genetic neuromuscular disease, or respiratory dysfunction associated with bronchial hyperresponsiveness, where said semi-synthetic derivative of 20-hydroxyecdysone is selected from a compound of general formula (I), where R¹ is selected from: the group (C₁-C₆)W(C₁-C₆); groups (C₁-C₆)W(C₁-C₆)W(C₁-C₆); groups (C₁-C₆)W(C₁-C₆)CO₂(C₁-C₆); group (C₁-C₆)A, where A is a hetero-ring, optionally substituted by a group like OH, OMe, (C₁-C₆), N(C₁-C₆), CO₂(C₁-C₆); CH₂Br groups; W is a heteroatom selected from N, O and S, preferably O and even more preferably S; and compounds of general formula (II).

EFFECT: improvement of respiratory function in mammals with a genetic or acquired neuromuscular disease or with impaired respiratory function associated with bronchial hyperreactivity.

13 cl, 27 dwg