IL-8 INHIBITORS FOR USE IN TREATMENT AND/OR PREVENTION OF SECONDARY BACTERIAL INFECTIONS Russian patent published in 2022 - IPC A61K31/427 A61P31/04 

FIELD: medicine.

SUBSTANCE: present invention relates to the field of medicine and discloses the use of IL-8 inhibitor for the prevention and/or treatment of secondary bacterial respiratory infections related to a previous flu infection. IL-8 inhibitor is molecules with low molecular weight, which inhibit IL-8 activity mediated with CXCR1 receptor or both CXCR1 and CXCR2 receptors, and which are a compound of the formula (II) or pharmaceutically acceptable salt of such a compound. In this case, R⁴ is linear or branched C₁-C₆ alkyl, benzoyl, phenoxy, trifluoromethanesulfonyloxy; R⁵ is H or linear or branched C₁-C₃ alkyl; R⁶ is linear or branched C₁-C₆ alkyl or trifluoromethyl. Alternatively, molecules are a compound of the formula (III) or pharmaceutically acceptable salt of such a compound, where R' is hydrogen; R is H or a residue of the formula SO₂Ra, where Ra is linear or branched C₁-C₄ alkyl or halogen C₁-C₃ alkyl.

EFFECT: efficiency of IL-8 inhibitor for the prevention and/or treatment of secondary bacterial respiratory infections related to a preliminary flu infection.

(II),

(III)

7 cl, 11 dwg, 2 ex