FIELD: medicine.
SUBSTANCE: present invention relates to the field of medicine and discloses the use of IL-8 inhibitor for the prevention and/or treatment of secondary bacterial respiratory infections related to a previous flu infection. IL-8 inhibitor is molecules with low molecular weight, which inhibit IL-8 activity mediated with CXCR1 receptor or both CXCR1 and CXCR2 receptors, and which are a compound of the formula (II) or pharmaceutically acceptable salt of such a compound. In this case, R4 is linear or branched C1-C6 alkyl, benzoyl, phenoxy, trifluoromethanesulfonyloxy; R5 is H or linear or branched C1-C3 alkyl; R6 is linear or branched C1-C6 alkyl or trifluoromethyl. Alternatively, molecules are a compound of the formula (III) or pharmaceutically acceptable salt of such a compound, where R' is hydrogen; R is H or a residue of the formula SO2Ra, where Ra is linear or branched C1-C4 alkyl or halogen C1-C3 alkyl.
EFFECT: efficiency of IL-8 inhibitor for the prevention and/or treatment of secondary bacterial respiratory infections related to a preliminary flu infection.
(II),
(III)
7 cl, 11 dwg, 2 ex
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Authors
Dates
2022-10-11—Published
2018-05-28—Filed