FIELD: biotechnology; genetic engineering; immunology.
SUBSTANCE: tetravalent vector vaccine has been obtained for the prevention of dengue fever, containing a recombinant vector based on a modified vaccinia virus strain Ankara (MVA) with an integrated nucleotide sequence encoding the d34 antigen (46.5 kDa), which consists of four DHI domains of the E-protein of dengue virus serotypes 1, 2, 3 and 4, connected by a flexible linker 2x(GGGGS).
EFFECT: method has been proposed for using a tetravalent vector vaccine to induce a specific immune response against four serotypes of the dengue virus, including administering the vaccine into the body of a mammal in an effective dosage.
2 cl, 5 dwg, 3 tbl, 8 ex
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Authors
Dates
2024-01-26—Published
2023-10-10—Filed