FIELD: biotechnology; immunology; virology.
SUBSTANCE: group of inventions relates to the field of biotechnology, immunology and virology. An immunobiological agent for the prevention of diseases caused by tick-borne encephalitis virus has been created based on a recombinant virus of the Flavivirus genus obtained using genetic engineering, reverse genetics and de novo gene synthesis and is a vector yellow fever virus in which part of the capsid (C) protein is premembrane (prM) and envelope (E) proteins are replaced by part of the capsid (C) protein, premembrane (prM) and envelope (E) proteins of 493 tick-borne encephalitis virus strains. The first vector virus may be a yellow fever virus, namely the YF17DD-UN strain. In addition, the recombinant virus may be the YF17DD-UN/TBE493 virus.
EFFECT: group of inventions expands the arsenal of means for induction of specific immunity against diseases caused by tick-borne encephalitis virus.
5 cl, 7 dwg, 4 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| mRNA-BASED IMMUNOBIOLOGICAL AGENT FOR PREVENTION OF DISEASES CAUSED BY TICK-BORNE ENCEPHALITIS VIRUS | 2024 |
|
RU2823754C1 |
| METHOD OF PREPARING IMMUNOGENIC COMPOSITION BASED ON THREE FUSION PROTEINS OF SHELL OF TICK-BORNE ENCEPHALITIS VIRUS DEFINING BELONGING TO SIBERIAN (DBD2-D3S), EUROPEAN (DBD2-D3E) AND FAR EAST (DBD2-D3D) VIRUS SUBTYPES; RECOMBINANT PLASMIDS pDBD2-D3S, pDBD2-D3E AND pDBD2-D3D; PRODUCER STRAINS Escherichia coli M15 [pREP4]; CHIMERIC PROTEINS AND THEIR APPLICATION | 2014 |
|
RU2560588C1 |
| RECOMBINANT PLASMID DNA PC-NS3 PROVIDING INTEGRATION OF COMPLEX OF GENES C, PRM, E, NS1, NS 2A, NS 2B, NS3 OF TICK-BORNE ENCEPHALITIS VIRUS IN GENOME OF BOVINE VACCINE VIRUS AND RECOMBINANT STRAIN OF BOVINE VACCINE VIRUS EXPRESSING COMPLEX OF GENES C, PRM, E, NS1, NS 2A, NS2B, NS3 OF TICK-BORNE ENCEPHALITIS VIRUS IN IMMUNIZED ORGANISM CELLS | 1995 |
|
RU2112038C1 |
| FLAVIVIRUS WITH BIPARTITE GENOME AND USING IT | 2008 |
|
RU2527891C2 |
| METHOD FOR TICK-BORNE ENCEPHALITIS VIRUS DETECTION BY REAL-TIME RT-PCR METHOD | 2019 |
|
RU2744187C1 |
| RECOMBINANT PLASMID pHis6-flagG-protE, WHICH PROVIDES SYNTHESIS OF A RECOMBINANT CHIMERIC PROTEIN, INCLUDING EPITOPES OF GLYCOPROTEIN E OF TICK-BORNE ENCEPHALITIS VIRUS AND FLAGELLIN G SALMONELLA TYPHII AND USED AS A BASE FOR VACCINE AGAINST TICK-BORNE ENCEPHALITIS VIRUS | 2018 |
|
RU2702716C2 |
| INFECTIOUS CLONES OF FULL-SIZED CDNA OF TICK FLAVIVIRUS | 2001 |
|
RU2288266C2 |
| CHIMERIC FLAVIVIRAL VACCINES | 1998 |
|
RU2209082C2 |
| PVEAL3-10H10CH PLASMID GENETIC CONSTRUCT, STRAIN OF CHO-K1-10H10CH RECOMBINANT CELL LINE AND 10H10CH CHIMERIC ANTIBODY AGAINST TICK-BORNE ENCEPHALITIS VIRUS PRODUCED BY THE INDICATED STRAIN OF CHO-K1-10H10CH CELL LINE | 2022 |
|
RU2800471C1 |
| RECOMBINANT PLASMID DNA pET160-E3-YFV EXPRESSING AN ANALOGUE OF THE THIRD DOMAIN OF THE SURFACE PROTEIN E OF THE YELLOW FEVER VIRUS (YFV) IN THE BACTERIAL SYSTEM OF E. COLI USED TO DETECT SPECIFIC ANTIBODIES OF YFV | 2022 |
|
RU2798563C1 |
