JAK INHIBITOR AND METHOD OF ITS OBTAINING Russian patent published in 2024 - IPC C07D487/04 A61K31/519 A61K31/541 A61P1/00 A61P1/04 A61P17/00 A61P19/02 A61P29/00 A61P35/00 A61P35/02 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound represented by general formula I, or a pharmaceutically acceptable salt or stereoisomer thereof, which has an inhibitory effect on JAK kinase. In the formula, IA represents C; R₅ represents H; X represents R represents C_1-10 linear or branched alkyl; Y represents R₃ and R₄ represent H; m is any integer from 1 to 3, in particular 1, 2 or 3; Z represents C_3-12-cycloalkyl; R₁ and R₂ are each optionally H, C_1-10 linear or branched alkyl, where the H on the carbon atom may be replaced by groups such as -N(C_0-10-alkyl)(C_0-10-alkyl), -OC_0-10-alkyl, C_3-10-cycloalkyl, C_6-18-aryl, -N-heterocycloaryl, -O-heterocycloaryl or -S-heterocycloaryl; where H on C_6-18-aryl or heterocycloaryl can be replaced by a halogen group or C_1-4 linear alkyl; each R₇ and R₈ represents H. The invention also relates to a method of producing a compound represented by the general formula I, a pharmaceutical composition comprising the said compound, and its use in the preparation of a medicinal product intended for the treatment of a disease associated with the JAK-STAT signaling pathway, including for the prevention and/or treatment of inflammatory or oncological diseases.

EFFECT: obtaining of JAK inhibitor and a method of its obtaining.

12 cl, 2 tbl, 9 ex