DERIVATIVES OF CARBOXY-SUBSTITUTED (HETERO)AROMATIC RINGS, METHOD OF SYNTHESIS AND USE THEREOF Russian patent published in 2020 - IPC C07C255/52 C07D209/08 C07D209/42 C07D215/48 C07D231/56 C07D235/06 C07D261/20 C07D263/56 C07D263/58 C07D307/79 C07D307/82 C07D307/84 C07D317/62 C07D333/72 C07D471/04 A61K31/277 A61K31/36 A61K31/381 A61K31/343 A61K31/404 A61K31/4184 A61K31/416 A61K31/42 A61K31/423 A61K31/437 A61K31/47 A61P13/02 A61P19/02 A61P19/06 

Abstract RU 2733750 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to compounds of general formula (I), U is phenyl; each of R1 and R2 independently represents H, D, OH or C1-6-halogenalkyl; T is NO2, CN or CF3; X is CR4 or N; R4 is H; each of Y and Z independently represents C, CH or N; is a single or double bond; Q is phenyl, C4-7 carbocycle, 5-member heterocycle containing 1–2 heteroatoms, which are independently selected from O, S or N, or 5–6-member heteroaromatic ring containing 1–2 heteroatoms independently selected from O, S or N; each R3 independently represents H, D, halogen, C1-6-alkyl, C1-6-haloalkyl or 3–8-member cycloalkyl; m is 0 or 1; and n equals 0, 1, 2 or 3; as well as to their esters and pharmaceutically acceptable salts.

EFFECT: technical result is compounds of formula (I) as inhibitors of xanthine oxidase (XO) and carriers of 1 urate (URAT1).

11 cl, 3 tbl, 43 ex

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RU 2 733 750 C2

Authors

Yang Xinye

Huang Changwei

Ma Facheng

Zhang Ji

Wang Xiaojun

Zhang Yingjun

Dates

2020-10-06Published

2016-08-31Filed