FIELD: pharmaceuticals.
SUBSTANCE: invention relates to compounds of general formula (I), U is phenyl; each of R1 and R2 independently represents H, D, OH or C1-6-halogenalkyl; T is NO2, CN or CF3; X is CR4 or N; R4 is H; each of Y and Z independently represents C, CH or N; is a single or double bond; Q is phenyl, C4-7 carbocycle, 5-member heterocycle containing 1–2 heteroatoms, which are independently selected from O, S or N, or 5–6-member heteroaromatic ring containing 1–2 heteroatoms independently selected from O, S or N; each R3 independently represents H, D, halogen, C1-6-alkyl, C1-6-haloalkyl or 3–8-member cycloalkyl; m is 0 or 1; and n equals 0, 1, 2 or 3; as well as to their esters and pharmaceutically acceptable salts.
EFFECT: technical result is compounds of formula (I) as inhibitors of xanthine oxidase (XO) and carriers of 1 urate (URAT1).
11 cl, 3 tbl, 43 ex
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Authors
Dates
2020-10-06—Published
2016-08-31—Filed