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(19)

(11)

2 764 666

(13)

(51)

IPC

C07D401/14(2006-01-01)

C07D403/04(2006-01-01)

C07D403/14(2006-01-01)

C07D405/14(2006-01-01)

C07D417/14(2006-01-01)

C07D471/04(2006-01-01)

A61K31/4184(2006-01-01)

A61K31/4188(2006-01-01)

A61K31/437(2006-01-01)

A61K31/501(2006-01-01)

A61P3/00(2006-01-01)

A61P9/00(2006-01-01)

A61K35/00(2006-01-01)

(21) (22)

Application

2019123854, 2017-12-22

(24)

Start date

2017-12-22

(22)

Actual filing date

2017-12-22

(45)

Published

2022-01-19

(72)

Inventor

Sparks, StivenEjts, Kristofer, M.Shever, Semmi, R.Khoekstra, Uillyam, Dzh.

(73)

Holder

Seleniti Terapyutiks Ltd.

COMPOUNDS INHIBITING METALLOENZYMES Russian patent published in 2022 - IPC C07D401/14 C07D403/04 C07D403/14 C07D405/14 C07D417/14 C07D471/04 A61K31/4184 A61K31/4188 A61K31/437 A61K31/501 A61P3/00 A61P9/00 A61K35/00

Abstract RU 2764666 C2

FIELD: medicine.

SUBSTANCE: invention relates to a compound selected from:

and

A method for inhibiting and modulating the activity of aldosterone synthase metalloenzyme (CYP11B2), methods for treating diseases or disorders caused by such a metalloenzyme, and a pharmaceutical composition are also proposed.

EFFECT: proposed compounds are capable of inhibiting the activity of aldosterone synthase metalloenzymes (CYP11B2) and can be used to treat diseases or disorders caused by such a metalloenzyme.

15 cl, 5 tbl, 137 ex

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RU 2 764 666 C2

Authors

Sparks, Stiven

Ejts, Kristofer, M.

Shever, Semmi, R.

Khoekstra, Uillyam, Dzh.

Dates

2022-01-19—Published

2017-12-22—Filed