2-(1,1-DIMETHYL-1H-BENZO[E]INDOLIN-2-YL)-5,6,7-TRICHLORO-1,3-TROPOLONE, WHICH HAS CYTOTOXIC ACTIVITY AGAINST A431 SKIN CANCER AND H1299 LUNG CANCER CELL CULTURES Russian patent published in 2023 - IPC C07D209/60 A61K31/404 A61P35/00 

Abstract RU 2810581 C1

FIELD: organic chemistry.

SUBSTANCE: invention relates to 2-(1,1-dimethyl-1H-benzo[e]indolin-2-yl)-5,6,7-trichloro-1,3-tropolone of formula 1, which has cytotoxic activity against the culture of skin cancer cells A431 and lung cancer H1299 and can find application in the production of antitumor drugs.

(1)

EFFECT: obtaining 2-(1,1-Dimethyl-1H-benzo[e]indolin-2-yl)-5,6,7-trichloro-1,3-tropolone, which has cytotoxic activity against A431 skin cancer and H1299 lung cancer cell cultures.

10 cl, 1 ex

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RU 2 810 581 C1

Authors

Minkin Vladimir Isaakovich

Kit Oleg Ivanovich

Saiapin Iurii Anatolevich

Maksimov Aleksei Iurevich

Goncharova Anna Sergeevna

Gusakov Evgenii Aleksandrovich

Tupaeva Inna Olegovna

Krasnikova Tatiana Anatolevna

Kuznetsova Natalia Sergeevna

Filippova Svetlana Iurevna

Chembarova Tatiana Vladimirovna

Dates

2023-12-27Published

2023-11-08Filed