FIELD: biotechnology.
SUBSTANCE: method of inhibiting PD-1/PD-L1 signalling pathway in bladder cancer cells by interacting with Mycobacterium bovis BCG-1 vaccine strain. The effect of the invention is achieved by using Mycobacterium bovis BCG-1 vaccine strain. This method can be performed both in vitro and in vivo. The developed method of reducing the expression of PD-L1 in bladder cancer cells can be used in the development of new drugs against bladder cancer, as well as new treatment regimens for bladder cancer.
EFFECT: increasing the effectiveness of adjuvant therapy for bladder cancer.
4 cl, 5 dwg, 3 ex
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