ANTI-VIRAL COMPOSITIONS OF WIDE SPECTRUM OF ACTION AND METHODS Russian patent published in 2024 - IPC C07D417/14 A61K31/427 A61K31/4709 A61P31/12 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula I and its pharmaceutically acceptable salt or solvate, a pharmaceutical composition based on them, as well as a method of treating or preventing a viral infection and a method of inhibiting virus production using them. In the general formula I, one of X1 and X2 is N and the other is S; X3 and X4 are independently selected from C and N; and when X3 is C, it is optionally substituted with isopropyl; one of R1 and R2 is H, and the other is a 5- or 6-membered aryl or cycloalkyl with 1-3 ring heteroatoms independently selected from N and O, and substituted with 0-2 groups independently selected from: =O, C_1-6 straight or branched chain alkyl, optionally substituted with -OR12; or R1 and R2 together form an unsubstituted or 6-membered cycloalkyl with 2 ring heteroatoms representing O; R3 is selected from H, -C≡N, straight or branched C_1-4 alkoxy, -SO₂(C_1-6 alkyl), and ring structure containing 5- or 6-membered aryl or 4-, 5- or a 6-membered cycloalkyl with 1 or 2 ring heteroatoms independently selected from N, O and S, and substituted with 0-2 groups independently selected from =O, C_1-6 straight or branched chain alkyl, and C_1-6 straight or branched chain alkoxy; R4 is selected from H, -C≡N, C_1-4 straight or branched chain alkoxy, -SO₂(C_1-6 alkyl), -C(O)NH₂, ring structure containing 5-membered aryl or 5 - or a 6-membered cycloalkyl with 2 ring heteroatoms independently selected from N, O and S, and substituted with 0-2 groups representing =O; R5 represents H; R6 represents H; and R12 is independently, in each case, selected from straight or branched chain C_1-4 alkyl.

EFFECT: obtaining an anti-viral compositions of a wide spectrum of action and methods.

22 cl, 6 dwg, 2 tbl, 68 ex