DERIVATIVE WITH ARTICULATED RINGS AND METHOD FOR PREPARATION THEREOF, INTERMEDIATE COMPOUND, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF Russian patent published in 2019 - IPC C07D217/24 C07D495/04 A61K31/472 A61K31/4365 A61P3/06 A61P3/10 A61P9/10 A61P9/12 A61P13/12 A61P19/06 

FIELD: organic chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to a heterocyclic compound of formula II or IV, to its racemate, enantiomer, diastereoisomer or a pharmaceutically acceptable salt, where M is H or Na ion; U represents , or ; X¹ represents CH, Y represents ; each of X⁷ and X⁸ independently represents CH or S; each of R¹ and R² independently represents H, C_1-4 alkyl; or R¹, R² together with the carbon atom to which they are attached form C_3-6 cycloalkyl; wherein alkyl may be further substituted with 3 D substituents; R³ is H or halogen; R⁴ represents C_6-10 aryl or ; wherein aryl or is substituted with 1–2 substituents selected from the group consisting of halogen and CN; each of R⁵ and R⁶ independently represents H, OH or C_1-4 alkyl; n is 0 or 1; p is 1; or a derivative with articulated rings, which is selected from the compounds mentioned in claim 1 of the claims. Invention also relates to intermediate compounds of formulas II-a or IV-a, the use of a compound of formula II or IV and a pharmaceutical composition based on a compound of formula II or IV.

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EFFECT: technical result: new heterocyclic compounds have been obtained that are useful in the treatment of hyperuricemia or a disease associated with hyperuricemia.

12 cl, 1 ex, 1 tbl