BIODEGRADABLE IMPLANT FOR LOCAL IMMUNOTHERAPY OF CANCER PATIENTS Russian patent published in 2022 - IPC A61K47/69 A61F2/00 A61K35/17 

Abstract RU 2780932 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, medicine and veterinary medicine, namely oncology, the development of submersible medical devices for personalized therapy, in particular for local cytoreductive therapy of patients with solid tumors by paratumoral implantation of the product. A biodegradable implant for local immunotherapy of cancer patients is a scaffold made of a biodegradable alloy based on iron and manganese, made in the form of a plate with oblong slits forming reservoirs for the active composition filled with a cell-mobilizing medium based on hydrogel and a biomedical cell product based on autologous or allogeneic T-lymphocytes and natural killers activated ex vivo.

EFFECT: invention provides targeted transportation and long-term survival of cells deposited in the hydrogel in the area of administration, as well as the implementation of prolonged local cytotoxic effects of effector cells on tumor cells by direct cytotoxic effects, as well as activation of specific and non-specific links of the patient’s immunity.

1 cl, 2 dwg, 2 ex

Similar patents RU2780932C1

Title Year Author Number
BIODEGRADABLE METAL IMPLANT FOR LOCAL IMMUNOTHERAPY OF PATIENTS WITH SOLID TUMORS 2021
  • Anisimova Natalya Yurevna
  • Martynenko Natalya Sergeevna
  • Rybalchenko Olga Vladislavovna
  • Kiselevskij Mikhail Valentinovich
  • Mansharipova Almagul Tuleulovna
  • Kabieva Ajgul Odakovna
  • Dobatkin Sergej Vladimirovich
  • Estrin Yurij Zakharovich
RU2780927C1
TITANIUM IMPLANT WITH THE FUNCTION OF LOCAL IMMUNOTHERAPY FOR OSTEORECONSTRUCTIVE SURGERY AND PREVENTION OF LOCAL RECURRENCE OF ONCOLOGICAL DISEASE AND METHOD FOR ITS MANUFACTURE 2021
  • Straumal Boris Borisovich
  • Anisimova Natalya Yurevna
  • Kogtenkova Olga Aleksandrovna
  • Kiselevskij Mikhail Valentinovich
RU2779367C1
SUBCUTANEOUS BIODEGRADABLE IMPLANT FOR DELAYED HEMOSTIMULATION OF CANCER PATIENTS 2023
  • Anisimova Natalya Yurevna
  • Filonenko Dmitrij Vladimirovich
  • Martynenko Natalya Sergeevna
  • Rybalchenko Olga Vladislavovna
  • Shinkareva Mariya Vladimirovna
  • Rybalchenko Georgij Vladimirovich
  • Ustyuzhanina Nadezhda Evgenevna
  • Kiselevskij Mikhail Valentinovich
RU2809091C1
BIOMEDICAL CELL PRODUCT FOR TREATMENT OF MALIGNANT NEOPLASMS 2023
  • Kiselevskij Mikhail Valentinovich
  • Chikileva Irina Olegovna
  • Zamkova Mariya Anatolevna
  • Kazanskij Dimitrij Borisovich
  • Persiyantseva Nadezhda Aleksandrovna
  • Khromykh Lyudmila Mendelevna
  • Bruter Aleksandra Vladimirovna
  • Shatunova Polina Olegovna
RU2813531C1
BIOMEDICAL CELL PRODUCT WITH ANTI-HER2 SPECIFIC ANTI-TUMOUR ACTIVITY 2019
  • Kiselevskij Mikhail Valentinovich
  • Petkevich Alisa Antonovna
  • Chikileva Irina Olegovna
  • Anisimova Natalya Yurevna
RU2728361C1
CELL PRODUCT FOR LOADING AND ACTIVATION OF HUMAN DENDRITE CELLS 2019
  • Baldueva Irina Aleksandrovna
  • Danilova Anna Borisovna
  • Nekhaeva Tatyana Leonidovna
  • Avdonkina Natalya Aleksandrovna
  • Emelyanova Natalya Viktorovna
  • Belyaev Aleksej Mikhajlovich
RU2714208C1
BIOMEDICAL CELL PRODUCT WITH SPECIFIC ANTITUMOR ACTIVITY, REPRESENTED BY POPULATIONS OF LYMPHOKINE-ACTIVATED KILLERS AND ANTI-HER2 CAR-γδΤ-OIL AND ANTI-HER2 CAR-T-NK 2022
  • Kiselevskij Mikhail Valentinovich
  • Petkevich Alisa Antonovna
  • Lipengolts Aleksej Andreevich
  • Chikileva Irina Olegovna
  • Anisimova Natalya Yurevna
RU2786210C1
METHOD FOR TARGETED DELIVERY OF THERAPEUTIC DRUGS TO TUMOR CELLS 2022
  • Straumal Boris Borisovich
  • Anisimova Natalya Yurevna
  • Kogtenkova Olga Aleksandrovna
  • Kiselevskij Mikhail Valentinovich
RU2789807C1
METHOD OF IMMUNOTHERAPY WITH BONE-MARROW PRECURSORS OF DENDRITE CELLS, SENSIBILISED WITH PHOTOMODIFIED TUMOR CELLS IN VIVO, FOR PATIENTS DISSEMINATED WITH SOLID TUMORS 2008
  • Moiseenko Vladimir Mikhajlovich
  • Baldueva Irina Aleksandrovna
  • Gel'Fond Mark L'Vovich
  • Orlova Rashida Vakhidovna
  • Fakhrutdinova Ol'Ga Leonidovna
  • Danilova Anna Borisovna
  • Danilov Aleksej Olegovich
  • Nekhaeva Tat'Jana Leonidovna
  • Novik Aleksej Viktorovich
  • Imjanitov Evgenij Naumovich
RU2376033C1
IMMUNOTHERAPY METHOD FOR TREATING PATIENTS FOR SOLID TUMORS BY APPLYING TUMOR LYSATE WITH BETALEUKINE ADJUVANT 2004
  • Moiseenko Vladimir Mikhajlovich
  • Baldueva Irina Aleksandrovna
  • Orlova Rashida Vakhidovna
  • Semenova Anna Igorevna
  • Simbirtsev Andrej Semenovich
RU2267326C2

RU 2 780 932 C1

Authors

Anisimova Natalya Yurevna

Martynenko Natalya Sergeevna

Rybalchenko Olga Vladislavovna

Kiselevskij Mikhail Valentinovich

Mansharipova Almagul Tuleulovna

Kabieva Ajgul Odakovna

Dobatkin Sergej Vladimirovich

Estrin Yurij Zakharovich

Dates

2022-10-04Published

2021-11-25Filed