BIODEGRADABLE IMPLANT FOR LOCAL IMMUNOTHERAPY OF CANCER PATIENTS Russian patent published in 2022 - IPC A61K47/69 A61F2/00 A61K35/17 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, medicine and veterinary medicine, namely oncology, the development of submersible medical devices for personalized therapy, in particular for local cytoreductive therapy of patients with solid tumors by paratumoral implantation of the product. A biodegradable implant for local immunotherapy of cancer patients is a scaffold made of a biodegradable alloy based on iron and manganese, made in the form of a plate with oblong slits forming reservoirs for the active composition filled with a cell-mobilizing medium based on hydrogel and a biomedical cell product based on autologous or allogeneic T-lymphocytes and natural killers activated ex vivo.

EFFECT: invention provides targeted transportation and long-term survival of cells deposited in the hydrogel in the area of administration, as well as the implementation of prolonged local cytotoxic effects of effector cells on tumor cells by direct cytotoxic effects, as well as activation of specific and non-specific links of the patient’s immunity.

1 cl, 2 dwg, 2 ex