METHOD OF PRODUCING TERTIARY ALCOHOLS BY REACTION OF ARYLOLEFINS WITH AlCl AND KETONES UNDER INFLUENCE OF CpZrCl CATALYST Russian patent published in 2024 - IPC C07C29/38 C07C33/20 C07C33/34 C07C41/30 C07C43/23 

FIELD: organic chemistry.

SUBSTANCE: invention relates to a method of producing tertiary alcohols of general formula (1):

of interest as starting synthons for the creation of biologically active compounds for medical purposes and the creation of photoresistant coatings. The method involves the interaction of aryl olefins with ketones in an argon atmosphere in the presence of a catalyst Cp₂ZrCl₂, an aluminum derivative, magnesium powder, in tetrahydrofuran, at 20°C, atmospheric pressure, for 8 hours. Aluminum chloride AlCl₃ is used as an aluminum derivative, Ar-CH=CH₂ compounds are used as aryl olefins (Ar = Ph, o -, p -methylphenyl, 4-tert -butoxyphenyl, naphthyl), and the compounds R'COR'' as ketones, (where R'=Me, Bu, R''= Me, Et, Bu, Hex, Hep, c -Bu, i -Bu). Arylolefin molar ratio: AlСl₃: R'COR'': Mg: [Zr] = 1:2:1:2:0.1.

EFFECT: production of target products in high yield using cheap, easy-to-use AlCl₃.

1 cl, 1 tbl, 16 ex