FIELD: organic chemistry; medicine.
SUBSTANCE: invention relates to ubiquitin-specific protease 7 (USP7) protein inhibitor molecules used for treating malignant growths, wherein said inhibitors have formula (I), where A, B, R1, R2, R3, X, z are defined in the patent claim.
EFFECT: invention widens the range of USP7 inhibitors as medicinal agents for treating oncological diseases, provides an increase in the favorable effect on the survival rate of organisms in the treatment of malignant neoplasms, for example, such as multiple myeloma, colorectal cancer, prostate cancer, ovarian cancer, bladder cancer, urogenital cancer, squamous cell carcinoma of the esophagus, chronic lymphatic leukemia, medulloblastoma, colon cancer, breast cancer, liver cancer, kidney cancer, pancreatic cancer, lung cancer, neuroblastoma, osteosarcoma or acute myeloid leukemia.
6 cl, 19 dwg, 3 tbl, 10 ex
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