FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry, specifically to a method of producing 1 (11)H-2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole of formula (I), which is the initial product in the synthesis of biologically active compounds. Method of producing desired diazepinobenzimidazole is characterized by that isoindoline-1,3-dione is treated with dibromobutane, then obtained 2-(4-bromobutyl) isoindoline-1,3-dione is reacted with 2-(methylthio)-1H-benzo[d]imidazole, obtained 2-(4-(2-(methylthio)-1H-benzo[d]imidazol-1-yl)butyl)isoindoline-1,3-dione is converted into the desired diazepinobenzimidazole of formula (I) by boiling with hydrazine hydrate.
EFFECT: simplification of the process technology due to reduction of the number of synthesis steps, use of available starting compounds and elimination of formation of by-products.
1 cl, 1 ex
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