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2 602 504

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IPC

C07D487/04(2006-01-01)

A61K31/551(2006-01-01)

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Application

2015133401/04, 2015-08-10

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Start date

2015-08-10

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Actual filing date

2015-08-10

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Published

2016-11-20

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Inventor

Divaeva Ljudmila NikolaevnaKuzmenko Tatjana AndreevnaAleshin Dmitrij AnatolevichSpasov Aleksandr AlekseevichMorkovnik Anatolij SavelevichAnisimova Vera AlekseevnaChepljaeva Natalja Ivanovna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovanija Federalnyj Universitet"Gosudarstvennoe Bjudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Professionalnogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet" Ministerstva Zdravookhranenija Rossijskoj Federatsii

HYDROGEN HALIDES OF 11-[(4-TERT-BUTYL)ETHYL]- AND 11-BENZYL-SUBSTITUTED 2,3,4,5-TETRAHYDRO[1,3]DIAZEPINO[1,2-A]BENZIMIDAZOLE, HAVING ALPHA-GLUCOSIDASE INHIBITORY ACTIVITY Russian patent published in 2016 - IPC C07D487/04 A61K31/551

Abstract RU 2602504 C1

FIELD: chemistry.

SUBSTANCE: invention relates to hydrogen halides of 11-[(4-tert-butylphenoxy)ethyl]- and 11-benzyl-substituted 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole of formula 1, having alpha-glucosidase inhibitory activity. In formula 1:

R=4-C(CH₃)₃C₆H₄OCH₂; 4-FC₆H₄; 4-CF₃C₆H₄; R¹=H, CH₃, X=Cl, Br; including under condition: 1a R=4-(CH₃)₃CC₆H₄OCH₂, R¹=H; 1b R=4-CF₃C₆H₄, R¹=H; 1c R=4-FC₆H₄, R¹=CH₃; 1d R=4-CF₃C₆H₄, R¹=CH₃.

EFFECT: obtaining novel compounds in series 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole, having alpha-glucosidase inhibitory activity.

1 cl, 3 ex

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RU 2 602 504 C1

Authors

Divaeva Ljudmila Nikolaevna

Kuzmenko Tatjana Andreevna

Aleshin Dmitrij Anatolevich

Spasov Aleksandr Alekseevich

Morkovnik Anatolij Savelevich

Anisimova Vera Alekseevna

Chepljaeva Natalja Ivanovna

Dates

2016-11-20—Published

2015-08-10—Filed