METHOD OF IMPROVING CONDITION OF DIGESTIVE SYSTEM Russian patent published in 2024 - IPC C07C233/29 A23L33/105 A61K31/165 A61K36/185 A61K36/21 A61K36/31 A61K36/67 A61K36/81 A61P1/14 

FIELD: medicine.

SUBSTANCE: group of inventions relates to a method of improving digestive function or gastrointestinal disorder and a method of treating or preventing a disease or disorder associated with the intestines. A method of improving digestive function or gastrointestinal distress, comprising providing an oral composition containing at least one carrier and an effective amount of a compound of formula (I) or a trans isomer thereof, or a pharmaceutically acceptable salt thereof

Formula (I)

where R¹, R⁸ are selected from hydroxyl; R² is selected from hydrogen, hydroxyl and –(O)C₁-₆ alkyl; R³, R⁴, R⁵, R⁶, R⁷ and R⁹ are selected from hydrogen; a dotted connection means there is a connection; X represents O; Z represents NR^a; and R^a is selected from hydrogen, wherein said gastrointestinal disorder is selected from the group consisting of irritable bowel syndrome, ulcerative colitis, celiac disease, chronic gastrointestinal disorder, gastrointestinal epithelial cell barrier disorder, necrotizing enterocolitis, nonspecific colitis, chronic colitis, HIV enteropathy, Helicobacter pylori gastritis, NSAID enteropathy/enteritis, inflammation of the small intestinal reservoir, intermittent or variegated bowel disease, inflammation of the ileum, extraintestinal inflammation, granulomatous inflammation, aphthous ulcers, transmural inflammation, microscopic colitis, diverticulitis, inflammation in the disconnected bowel, short bowel syndrome, gastrointestinal mucositis, chemotherapy-induced mucositis, radiation therapy-induced mucositis and interstitial cystitis. A method of treating or preventing a disease or disorder in a subject, comprising administering a therapeutically effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof to a subject in need thereof, wherein R¹, R⁸ are selected from hydroxyl; R² is selected from hydrogen, hydroxyl and -(O)C_1-6 alkyl; R³, R⁴, R⁵, R⁶, R⁷ and R⁹ are each hydrogen; a dotted connection means there is a connection; X represents O; Z represents NR^a; and R^a is selected from hydrogen; in this case, the specified disease or disorder is associated with the intestines.

EFFECT: provision of effective and safe improvement of digestive function and treating diseases or disorders associated with the intestines.

28 cl, 5 dwg, 4 tbl, 6 ex