3-(5-AMINO-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USE THEREOF IN TREATING DISEASES ASSOCIATED WITH ZINC FINGER PROTEIN 2 OF IKAROS (IKZF2) FAMILY Russian patent published in 2024 - IPC C07D401/04 C07D401/14 A61K31/454 A61K31/4545 A61P35/00 A61P35/02 

FIELD: chemistry.

SUBSTANCE: present invention relates to compounds based on 3-(5-amino-1-oxoisoindolin-2-yl) piperidine-2,6-dione, specifically to a compound of formula (I'), where each of X₁ and X₂ is independently H or halogen; R_x is H; each of R_a and R_b is independently H, or R_a and R_b together with the atom to which they are attached form =(O); R₁ is or ; R₂ is H or (C₁-C₆) alkyl; or R₅ is -OR₆ or -NR₇R_7'; R₆ is H, (C₁-C₆) alkyl, wherein alkyl is optionally substituted with one substituent independently selected from phenyl; each of R₇ and R_7' independently represents H, (C₁-C₆) alkyl, wherein alkyl is optionally substituted with one to three R₈; or R₇ and R_7' together with the nitrogen atom to which they are attached form 5-member heterocycloalkyl ring; each R₈ is -C(O)OH, (C₃-C₇) cycloalkyl, phenyl or 6-member heteroaryl containing 1 heteroatom selected from N, wherein cycloalkyl is optionally substituted with one to four R₁₀; each R₁₀ independently in each occurrence is (C₁-C₆) alkyl; n1 equals 1, 2 or 3; each of n2 and n3 independently equals 1; or its pharmaceutically acceptable salts. Invention also relates to a compound selected from a group of individual compounds, a pharmaceutical composition, a method for breaking down IKZF2, a method of treating a disease or disorder, a method of modulating IKZF2 protein levels, a method of reducing IKZF2 protein levels, use of the compound of formula (I') in the manufacture of a drug preparation for treating a disease or disorder, use of the compound of formula (I') in treating the disease or disorder.

EFFECT: obtaining novel compounds which can be used in treating diseases or disorders associated with zinc finger protein 2 of the IKAROS (IKZF2) family.

25 cl, 21 tbl, 34 ex

(I')