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(19)

(11)

2 815 715

(13)

(51)

IPC

A61K31/192(2006-01-01)

A61K31/216(2006-01-01)

A61K31/40(2006-01-01)

A61K31/4164(2006-01-01)

A61K31/4196(2006-01-01)

A61K31/426(2006-01-01)

A61K31/44(2006-01-01)

A61K31/4965(2006-01-01)

A61K31/4412(2006-01-01)

A61P37/00(2006-01-01)

A61P29/00(2006-01-01)

A61P17/04(2006-01-01)

C07C15/12(2006-01-01)

C07C69/78(2006-01-01)

C07C65/105(2006-01-01)

C07C233/64(2006-01-01)

C07D213/79(2006-01-01)

C07D241/24(2006-01-01)

C07D261/18(2006-01-01)

C07D277/64(2006-01-01)

C07D333/38(2006-01-01)

C07D257/04(2006-01-01)

(21) (22)

Application

2021130117, 2020-03-26

(24)

Start date

2020-03-26

(22)

Actual filing date

2020-03-26

(45)

Published

2024-03-20

(72)

Inventor

Jeger, AdamSelfridzh, BrendonSajns, MarkosMartinboro, EsterBem, MarkusKhuan, Limin

(73)

Holder

Esajent Farmasyutikals, Ink.

MAS-COUPLED G-PROTEIN X4 RECEPTOR MODULATORS AND RELATED PRODUCTS AND METHODS Russian patent published in 2024 - IPC A61K31/192 A61K31/216 A61K31/40 A61K31/4164 A61K31/4196 A61K31/426 A61K31/44 A61K31/4965 A61K31/4412 A61P37/00 A61P29/00 A61P17/04 C07C15/12 C07C69/78 C07C65/105 C07C233/64 C07D213/79 C07D241/24 C07D261/18 C07D277/64 C07D333/38 C07D257/04

Abstract RU 2815715 C2

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention relates to a compound having one of the following structures, or a pharmaceutically acceptable salt thereof:

Compound No. Structure 1-55 1-78 5-1 4-10 1-65 4-11 1-58 1-56 9-1 1-82 1-85 1-29 1-101 2-3 1-103 1-112 4-7 11-1

Invention also relates to a pharmaceutical composition and a method of treating MRGPR X4-dependent conditions based on said compound.

EFFECT: obtaining a novel compound and a pharmaceutical composition based thereon, which can be used in medicine for treating MRGPR X4-mediated diseases.

39 cl, 7 dwg, 70 tbl, 70 ex

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RU 2 815 715 C2

Authors

Jeger, Adam

Selfridzh, Brendon

Sajns, Markos

Martinboro, Ester

Bem, Markus

Khuan, Limin

Dates

2024-03-20—Published

2020-03-26—Filed