NOVEL AURORA KINASE INHIBITOR AND USE THEREOF Russian patent published in 2025 - IPC C07D401/14 C07D417/14 A61K31/4155 A61K31/454 A61P35/00 

FIELD: chemistry; medicine.

SUBSTANCE: invention relates to medical chemistry, specifically to a compound of formula (1), where "*" denotes a chiral centre; L is CH₂ or CO; R¹ and R² each independently represent H, halogen, CN, C1-C3 alkyl, C3-C6 cycloalkyl, C1-C3 alkoxy, C1-C3 haloalkyl and C1-C3 haloalkoxy; R³ is C2-C3 alkyl, C3-C6 cycloalkyl, C1-C3 haloalkyl, -(C1-C3)alkyl-OH, -(C1-C3)alkyl-(C1-C3)alkoxy, -(C1-C3)alkyl-CN or -(C1-C3)alkyl-NR⁵R⁶, where R⁵ and R⁶ each independently represent H or C1-C3 alkyl, or R⁵ and R⁶ form 4–7-membered heterocycloalkyl together with the N atom; R⁴ is H or F; W is a fragment (a), where R⁷ is H, C1-C3 alkyl or C3-C6 cycloalkyl.

EFFECT: obtaining compounds having inhibitory activity on Aurora kinase for treating diseases mediated by Aurora kinase.

5 cl, 5 tbl, 40 ex

(а).